clobazam vs fluvoxamine
Side-by-side comparison of clobazam and fluvoxamine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Dosage adjustment of clobazam oral suspension may be necessary when co-administered with strong CYP2C19 inhibitors (e.g., fluconazole, fluvoxamine, ticlopidine) or moderate CYP2C19 inhibitors (e.g., omeprazole) [see Clinical Pharmacology ( 12.3 )].
Recommendation: Your doctor might need to change your dose of clobazam to keep it at a safe level. Monitor yourself for increased drowsiness or trouble with coordination.
Onfi, Sympazan
Luvox
Clobazam oral suspension is a medicine used with other medicines to treat seizures caused by Lennox-Gastaut syndrome. It is a type of drug called a benzodiazepine.
Fluvoxamine is a medicine that can help treat obsessive compulsive disorder (OCD). It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs).
Clobazam oral suspension is used to treat seizures in people 2 years and older who have Lennox-Gastaut syndrome (LGS). LGS is a severe form of epilepsy that begins in childhood. This medicine helps to control seizures when used with other seizure medicines.
Fluvoxamine is used to treat obsessive compulsive disorder (OCD). OCD involves having constant, unwanted thoughts or behaviors that you feel the need to repeat. These thoughts or actions can cause you distress and interfere with your daily life.
Clobazam belongs to a class of drugs called benzodiazepines. It works by affecting certain chemicals in the brain that may be unbalanced in people with seizures. This helps to reduce the frequency of seizures.
Fluvoxamine works by increasing the amount of serotonin in your brain. Serotonin is a chemical that helps regulate mood. By increasing serotonin, fluvoxamine can help reduce the symptoms of OCD.
- • Constipation
- • Sleepiness or drowsiness
- • Fever
- • Sluggishness
- • Drooling
- • Abnormal ejaculation
- • Loss of appetite
- • Problems having an orgasm
- • Weakness
- • Diarrhea
- Seizure 4,619
- Sleepiness 1,798
- Medicine interaction 1,123
- Tiredness 1,090
- Epilepsy 805
- This medicine is interacting with another medicine 215
- Feeling sick to your stomach 117
- Sleepiness 114
- Feeling worried or nervous 103
- Thinking about suicide 96
Clobazam can cause serious side effects: * **Risk of Using with Opioids:** Taking clobazam with opioid medicines can cause severe sleepiness, slowed breathing, coma, and death. Only take them together if no other treatment works, and use the lowest dose for the shortest time. * **Risk of Abuse, Misuse, and Addiction:** Clobazam can be abused, misused, and lead to addiction, overdose or death. Your doctor will assess your risk before and during treatment. * **Risk of Dependence and Withdrawal:** Taking clobazam can lead to physical dependence. Stopping it suddenly can cause life-threatening withdrawal symptoms. To stop, your doctor will slowly lower your dose.
Antidepressants may increase the risk of suicidal thoughts or actions in children, teenagers, and young adults. Tell your doctor right away if you have any sudden changes in mood, behavior, thoughts, or feelings, especially if they are new, get worse, or worry you. Watch for suicidal thoughts or actions. Families and caregivers should also be aware of these risks.
Clobazam may harm your unborn baby. If you are pregnant or plan to become pregnant, talk to your doctor. There is a pregnancy registry for women who take anti-epilepsy drugs like clobazam. You can enroll by calling 1-888-233-2334.
Tell your doctor if you are pregnant or plan to become pregnant. Fluvoxamine may cause problems for the baby if taken during pregnancy. Fluvoxamine can pass into breast milk and may harm a nursing baby.
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How to Read This clobazam vs fluvoxamine Comparison
clobazam is classified in the Benzodiazepine (Anticonvulsant) drug class, while fluvoxamine sits within the Selective Serotonin Reuptake Inhibitor (SSRI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, clobazam has 9,435 submissions while fluvoxamine has 645. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to fluvoxamine interferes with how your body breaks down clobazam. this can lead to a buildup of clobazam in your bloodstream.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between clobazam and fluvoxamine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.