clarithromycin vs sildenafil
According to this portal's Publishing Organization, this page was last reviewed in August 2026 against our methodology. Figures and extracts on this site, including tables above 1,000 rows when the corpus is that large, are the publisher's responsibility.
Side-by-side comparison of clarithromycin and sildenafil. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Phosphodiesterase inhibitors: Sildenafil Tadalafil Vardenafil Use With Caution Sildenafil, Tadalafil, Vardenafil: Each of these phosphodiesterase inhibitors is primarily metabolized by CYP3A, and CYP3A will be inhibited by concomitant administration of clarithromycin. Co-administration of clarithromycin with sildenafil, tadalafil, or vardenafil will result in increased exposure of these phosphodiesterase inhibitors.
Biaxin
Viagra, Revatio
Clarithromycin is an antibiotic that fights bacterial infections. It belongs to a class of drugs called macrolides.
Sildenafil is a medicine used to treat erectile dysfunction (ED) in men. It helps increase blood flow to the penis to get and keep an erection.
Clarithromycin treats mild to moderate infections caused by certain bacteria. It can treat bronchitis, sinus infections, pneumonia, and throat/tonsil infections. It also treats skin infections, ear infections in children, certain mycobacterial infections, and H. pylori infections that cause ulcers.
Sildenafil is used to treat erectile dysfunction (ED), also known as impotence, in men. ED is when you cannot get or keep an erection firm enough for sex. Sildenafil helps by increasing blood flow to the penis when you are sexually stimulated.
Clarithromycin works by stopping the growth of bacteria. It prevents bacteria from making proteins they need to survive. This helps your body fight off the infection.
Sildenafil belongs to a class of drugs called PDE5 inhibitors. It works by relaxing the muscles and increasing blood flow to the penis during sexual stimulation. This helps you get and keep an erection.
- • Abdominal pain
- • Diarrhea
- • Nausea
- • Vomiting
- • Taste changes
- • Headache
- • Flushing (redness of the skin)
- • Upset stomach
- • Abnormal vision (blurred vision, changes in color vision)
- • Nasal congestion (stuffy nose)
- Drug Interaction 2,906
- Nausea 2,214
- Dyspnoea 1,959
- Diarrhoea 1,937
- Malaise 1,650
- Dyspnoea 7,729
- Headache 5,655
- Diarrhoea 4,447
- Nausea 3,984
- Death 3,873
Clarithromycin can cause severe allergic reactions. Stop taking it and get medical help right away if you have signs of a reaction. This medicine can also cause heart rhythm problems (QT prolongation) and liver problems. Tell your doctor if you have heart or liver issues. Clarithromycin may increase the risk of death in patients with coronary artery disease.
You should not take sildenafil if you are taking nitrates for chest pain, as this can cause a dangerous drop in blood pressure. If you have an erection that lasts longer than 4 hours, get medical help right away. Stop taking sildenafil and seek medical attention if you have a sudden loss of vision or hearing.
Clarithromycin is not recommended during pregnancy unless there are no other options. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if clarithromycin passes into breast milk, so talk to your doctor before breastfeeding.
Sildenafil is not for use in women. It is not known if sildenafil can harm an unborn baby or pass into breast milk.
Also Compare, Nearby Drugs
Compare clarithromycin with
Compare sildenafil with
How to Read This clarithromycin vs sildenafil Comparison
clarithromycin is classified in the Macrolide Antibiotic drug class, while sildenafil sits within the PDE5 Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, clarithromycin has 10,666 submissions while sildenafil has 25,688. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to clarithromycin stops your body from breaking down sildenafil normally, which can lead to higher and potentially unsafe levels of the drug in your blood.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for clarithromycin or sildenafil.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.