cilostazol vs ketoconazole
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of cilostazol and ketoconazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Reduce cilostazol tablets dose ( 2.2 , 7.1 ) 7.1 Inhibitors of CYP3A4 or CYP2C19 Inhibitors of CYP3A4 Coadministration of strong (e.g., ketoconazole) and moderate (e.g., erythromycin, diltiazem and grapefruit juice) CYP3A4 inhibitors can increase exposure to cilostazol.
Pletal
Nizoral
Cilostazol is a medicine that helps improve walking distance in people with leg pain due to poor circulation. It works by helping blood flow more easily through your blood vessels.
Ketoconazole shampoo is an antifungal medicine. It treats a fungal infection on your skin.
Cilostazol treats intermittent claudication. This is leg pain that happens when you walk because your leg muscles are not getting enough blood. Cilostazol helps to reduce the symptoms of this condition, like leg pain, by improving blood flow to your legs, so you can walk further without pain.
This shampoo treats tinea versicolor, a fungal infection. This infection can cause patches on your skin that are lighter or darker than the surrounding skin. These patches may appear on your trunk, neck, arms, and upper thighs.
Cilostazol is a phosphodiesterase III (PDE III) inhibitor. It works by relaxing the muscles in your blood vessels. This helps more blood flow to your legs and feet.
Ketoconazole is an antifungal medicine. It works by stopping the growth of the fungus. This helps to clear up the infection.
- • Headache
- • Diarrhea
- • Abnormal stools
- • Palpitation (feeling your heart beat)
- • Dizziness
No common side effects listed.
- Diarrhoea 302
- Fall 231
- Pneumonia 230
- Death 217
- Dyspnoea 209
- Fatigue 929
- Pruritus 902
- Nausea 834
- Rash 802
- Diarrhoea 760
You should not take cilostazol if you have heart failure. This medicine can be harmful if you have heart failure.
You should not use this shampoo if you are allergic to ketoconazole or any of the other ingredients.
It is not known if cilostazol is safe to take during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if cilostazol passes into breast milk. You should not breastfeed while taking cilostazol.
It is not known if ketoconazole shampoo can harm an unborn baby. Talk to your doctor if you are pregnant or breastfeeding before using this medicine.
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How to Read This cilostazol vs ketoconazole Comparison
cilostazol is classified in the PDE3 Inhibitor (Antiplatelet) drug class, while ketoconazole sits within the Azole Antifungal class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, cilostazol has 1,189 submissions while ketoconazole has 4,227. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to ketoconazole slows down how fast your body breaks down cilostazol. this causes the amount of cilostazol in your blood to increase.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for cilostazol or ketoconazole.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.