cilostazol vs erythromycin
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of cilostazol and erythromycin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Reduce cilostazol tablets dose ( 2.2 , 7.1 ) 7.1 Inhibitors of CYP3A4 or CYP2C19 Inhibitors of CYP3A4 Coadministration of strong (e.g., ketoconazole) and moderate (e.g., erythromycin, diltiazem and grapefruit juice) CYP3A4 inhibitors can increase exposure to cilostazol.
Pletal
E-Mycin, Ery-Tab
Cilostazol is a medicine that helps improve walking distance in people with leg pain due to poor circulation. It works by helping blood flow more easily through your blood vessels.
Erythromycin Topical Solution is a medicine that you put on your skin to treat acne. It contains an antibiotic to help clear up your skin.
Cilostazol treats intermittent claudication. This is leg pain that happens when you walk because your leg muscles are not getting enough blood. Cilostazol helps to reduce the symptoms of this condition, like leg pain, by improving blood flow to your legs, so you can walk further without pain.
Erythromycin Topical Solution treats acne vulgaris. This medicine helps to reduce acne on your face, neck, shoulders, chest, and back. It works by fighting the bacteria that cause acne.
Cilostazol is a phosphodiesterase III (PDE III) inhibitor. It works by relaxing the muscles in your blood vessels. This helps more blood flow to your legs and feet.
Erythromycin is a macrolide antibiotic. It works by stopping the growth of bacteria. This helps to reduce inflammation and clear up acne.
- • Headache
- • Diarrhea
- • Abnormal stools
- • Palpitation (feeling your heart beat)
- • Dizziness
- • Peeling
- • Dryness
- • Itching
- • Redness
- • Oily skin
- Diarrhoea 302
- Fall 231
- Pneumonia 230
- Death 217
- Dyspnoea 209
- Drug Hypersensitivity 4,088
- Nausea 1,271
- Vomiting 1,121
- Diarrhoea 1,069
- Dyspnoea 1,023
You should not take cilostazol if you have heart failure. This medicine can be harmful if you have heart failure.
You should not use this medicine if you are allergic to any of its ingredients.
It is not known if cilostazol is safe to take during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if cilostazol passes into breast milk. You should not breastfeed while taking cilostazol.
It is not known if erythromycin topical solution can harm an unborn baby. Talk to your doctor if you are pregnant or breastfeeding.
Also Compare, Nearby Drugs
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How to Read This cilostazol vs erythromycin Comparison
cilostazol is classified in the PDE3 Inhibitor (Antiplatelet) drug class, while erythromycin sits within the Macrolide Antibiotic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, cilostazol has 1,189 submissions while erythromycin has 8,572. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to erythromycin interferes with the way your body processes cilostazol. this leads to higher levels of cilostazol in your system.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for cilostazol or erythromycin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.