celecoxib vs furosemide
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Side-by-side comparison of celecoxib and furosemide. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Diuretics Clinical Impact: Clinical studies, as well as post-marketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics (e.g., furosemide) and thiazide diuretics in some patients. ( 7 ) Diuretics : NSAIDs can reduce natriuretic effect of furosemide and thiazide diuretics.
Celebrex
Lasix
Celecoxib (Celebrex) is a medicine that reduces pain and swelling. It belongs to a class of drugs called NSAIDs.
Furosemide is a water pill (diuretic). It helps your body get rid of extra water and salt.
Celecoxib treats the symptoms of osteoarthritis and rheumatoid arthritis. It can also help with juvenile rheumatoid arthritis in children 2 years and older. Additionally, it is used for ankylosing spondylitis, acute pain, and menstrual pain.
This medicine treats swelling (edema) from heart failure, liver problems, or kidney disease. It can also treat high blood pressure. Furosemide is helpful when you need a stronger diuretic.
Celecoxib blocks a substance in the body that causes pain and swelling. It targets COX-2, an enzyme involved in inflammation. By blocking COX-2, celecoxib reduces inflammation and relieves pain.
Furosemide works in your kidneys. It helps your kidneys remove more salt and water from your blood. This lowers the amount of fluid in your body and lowers blood pressure.
- • Abdominal pain
- • Diarrhea
- • Upset stomach
- • Gas
- • Swelling in your legs or feet
- • Dizziness
- • Headache
- • Blurred vision
- • Nausea
- • Vomiting
- Pain 12,294
- Arthralgia 10,923
- Fatigue 9,710
- Nausea 9,389
- Drug Hypersensitivity 7,713
- Dyspnoea 29,104
- Fatigue 20,393
- Diarrhoea 19,937
- Nausea 18,692
- Acute Kidney Injury 18,530
Celecoxib may increase your risk of serious heart problems like heart attack and stroke, which can be fatal. This risk may happen early in treatment and increases with longer use. You should not take celecoxib if you are having heart bypass surgery. Celecoxib can also increase the risk of serious stomach and intestine problems like bleeding, ulcers, and holes, which can be fatal. These problems can happen without warning. The elderly and those with a history of ulcers or GI bleeding are at higher risk.
Furosemide can cause you to lose too much fluid and electrolytes. This can lead to dehydration, low blood pressure, and kidney problems. Your doctor should check your blood regularly while you are taking this medicine.
Using celecoxib after about 20 weeks of pregnancy can cause kidney problems in the baby and low amniotic fluid. Avoid using celecoxib after 30 weeks of pregnancy because it can cause the baby's heart to close too early. If you are trying to get pregnant, talk to your doctor, as celecoxib may affect fertility.
Tell your doctor if you are pregnant or plan to become pregnant. Furosemide may not be safe during pregnancy. Talk to your doctor about the risks and benefits of taking this medicine while breastfeeding.
Also Compare, Nearby Drugs
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How to Read This celecoxib vs furosemide Comparison
celecoxib is classified in the COX-2 Selective NSAID drug class, while furosemide sits within the Loop Diuretic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, celecoxib has 50,029 submissions while furosemide has 106,656. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to this pain medicine can reduce the ability of your water pill to remove salt and extra fluid from your body.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for celecoxib or furosemide.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.