celecoxib vs cyclosporine
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of celecoxib and cyclosporine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Cyclosporine Clinical Impact: Concomitant use of celecoxib and cyclosporine may increase cyclosporine’s nephrotoxicity. Intervention: During concomitant use of celecoxib and cyclosporine, monitor patients for signs of worsening renal function.
Celebrex
Neoral, Sandimmune, Restasis
Celecoxib (Celebrex) is a medicine that reduces pain and swelling. It belongs to a class of drugs called NSAIDs.
Vevye eye drops contain cyclosporine. They help treat the signs and symptoms of dry eye disease.
Celecoxib treats the symptoms of osteoarthritis and rheumatoid arthritis. It can also help with juvenile rheumatoid arthritis in children 2 years and older. Additionally, it is used for ankylosing spondylitis, acute pain, and menstrual pain.
Vevye treats the signs and symptoms of dry eye disease. Dry eye can cause discomfort, stinging, and blurred vision. This medicine can help reduce these symptoms.
Celecoxib blocks a substance in the body that causes pain and swelling. It targets COX-2, an enzyme involved in inflammation. By blocking COX-2, celecoxib reduces inflammation and relieves pain.
Vevye contains cyclosporine, which is an immunosuppressant. It works by decreasing inflammation in the eyes. This helps your eyes make more tears.
- • Abdominal pain
- • Diarrhea
- • Upset stomach
- • Gas
- • Swelling in your legs or feet
- • Irritation where the drops are applied (8%)
- Pain 12,294
- Arthralgia 10,923
- Fatigue 9,710
- Nausea 9,389
- Drug Hypersensitivity 7,713
- Eye Irritation 7,786
- Pyrexia 4,064
- Eye Pain 3,808
- Nausea 3,623
- Diarrhoea 3,562
Celecoxib may increase your risk of serious heart problems like heart attack and stroke, which can be fatal. This risk may happen early in treatment and increases with longer use. You should not take celecoxib if you are having heart bypass surgery. Celecoxib can also increase the risk of serious stomach and intestine problems like bleeding, ulcers, and holes, which can be fatal. These problems can happen without warning. The elderly and those with a history of ulcers or GI bleeding are at higher risk.
To avoid eye injury or contamination, do not touch the bottle tip to your eye or any other surface. Do not use Vevye while wearing contact lenses. If you wear contacts, remove them before using the drops. You can put them back in 15 minutes after using Vevye.
Using celecoxib after about 20 weeks of pregnancy can cause kidney problems in the baby and low amniotic fluid. Avoid using celecoxib after 30 weeks of pregnancy because it can cause the baby's heart to close too early. If you are trying to get pregnant, talk to your doctor, as celecoxib may affect fertility.
It is not known if Vevye will harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Cyclosporine can pass into breast milk after being taken orally, but it is unknown if it passes into breast milk from eye drops. Talk to your doctor if you are breastfeeding.
How to Read This celecoxib vs cyclosporine Comparison
celecoxib is classified in the COX-2 Selective NSAID drug class, while cyclosporine sits within the Calcineurin Inhibitor (Immunosuppressant) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, celecoxib has 50,029 submissions while cyclosporine has 22,843. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to using these two drugs together can put extra stress on your kidneys and may cause them to work less effectively.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for celecoxib or cyclosporine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.