ceftazidime/avibactam vs probenecid
Side-by-side comparison of ceftazidime/avibactam and probenecid. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
7 DRUG INTERACTIONS 7.1 Probenecid In vitro , avibactam is a substrate of OAT1 and OAT3 transporters which might contribute to the active uptake from the blood compartment, and thereby its excretion. As a potent OAT inhibitor, probenecid inhibits OAT uptake of avibactam by 56% to 70% in vitro and, therefore, has the potential to decrease the elimination of avibactam when co-administered. Because a clinical interaction study of AVYCAZ or avibactam alone with probenecid has not been conducted, co-administration of AVYCAZ with probenecid is not recommended [ see Clinical Pharmacology ( 12.3 ) ] .
Recommendation: This combination is not recommended. Talk to your doctor about using a different medication.
Avycaz
Benemid
Avycaz is a drug that combines two medicines, ceftazidime and avibactam. It fights certain bacterial infections.
No summary available.
Avycaz treats complicated infections in the stomach area and urinary tract. This includes kidney infections. It also treats pneumonia that you get while in the hospital or from using a ventilator. Avycaz should only be used to treat infections that are proven or very likely to be caused by bacteria that it can kill.
Information not available.
Ceftazidime kills bacteria by attacking their cell walls. Avibactam helps ceftazidime work better by blocking certain enzymes that bacteria use to resist antibiotics. This allows ceftazidime to effectively kill the bacteria.
Information not available.
- • Diarrhea
- • Nausea
- • Vomiting
- • Rash
- • Irritation at the injection site
- • Diarrhea
- • Nausea
- • Yeast infection of the vagina
- • Headache
- • Vomiting
- Pyrexia 533
- Septic Shock 335
- Condition Aggravated 319
- Neutropenia 317
- Pneumonia 294
- Diarrhea 76
- Difficulty breathing 52
- Adenovirus infection 47
- Weakness 47
- Tiredness 46
Avycaz may cause a lower clinical response in adult patients with complicated intra-abdominal infections and kidney problems. Your kidney function should be checked daily. The dose of Avycaz may need to be adjusted if you have kidney problems. Avycaz can also cause severe allergic reactions and Clostridium difficile-associated diarrhea (CDAD). Seizures and other nervous system problems can also occur, especially if you have kidney problems.
No specific warnings noted.
It is not known if Avycaz will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Ceftazidime passes into breast milk, but it is not known if avibactam does. Talk to your doctor about the best way to feed your baby if you take Avycaz.
No pregnancy information available.
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How to Read This ceftazidime/avibactam vs probenecid Comparison
ceftazidime/avibactam is classified in the Cephalosporin / Beta-Lactamase Inhibitor drug class, while probenecid sits within the Uricosuric Agent class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, ceftazidime/avibactam has 1,798 submissions while probenecid has 268. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to probenecid blocks the body's ability to move the antibiotic out of the blood and into the urine. this causes the antibiotic levels to stay too high for too long.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between ceftazidime/avibactam and probenecid - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.