bupropion vs haloperidol
Side-by-side comparison of bupropion and haloperidol. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
( 7.1 ) Drugs metabolized by CYP2D6: Bupropion inhibits CYP2D6 and can increase concentrations of: antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, sertraline), antipsychotics (e.g., haloperidol, risperidone, thioridazine), beta-blockers (e.g., metoprolol), and Type 1C antiarrhythmics (e.g., propafenone, flecainide). Such drugs include certain antidepressants (e.g., venlafaxine, nortriptyline, imipramine, desipramine, paroxetine, fluoxetine, and sertraline), antipsychotics (e.g., haloperidol, risperidone, and thioridazine), beta-blockers...
Recommendation: Your doctor may need to lower your dose of haloperidol or watch you closely for side effects.
Wellbutrin, Zyban
Haldol
Bupropion is a medicine used to treat depression and prevent seasonal affective disorder (SAD). It can help improve your mood and energy levels.
Haloperidol is a medicine used to treat mental disorders. It can help reduce symptoms like hallucinations and confused thinking.
Bupropion is used to treat major depressive disorder (MDD), which can cause you to feel sad, lose interest in activities, and have trouble sleeping or eating. It is also used to prevent seasonal affective disorder (SAD), a type of depression that occurs during the fall and winter.
Haloperidol is used to manage symptoms of psychotic disorders. It can also control tics and vocal sounds in people with Tourette's Disorder. In children, it can treat severe behavior problems like being combative or overly excitable when other treatments haven't worked. It can also be used short-term for hyperactive children with impulsivity and difficulty paying attention.
Bupropion works by affecting certain chemicals in the brain called norepinephrine and dopamine. It helps to increase the levels of these chemicals, which can improve mood and reduce symptoms of depression.
Haloperidol works by changing the effect of certain natural chemicals in the brain. These chemicals, called neurotransmitters, affect mood and behavior. By blocking dopamine, haloperidol helps to reduce psychotic symptoms.
- • Dry mouth
- • Nausea
- • Trouble sleeping
- • Dizziness
- • Sore throat
- • Muscle stiffness
- • Shaking
- • Slow movement
- • Restlessness
- • Changes in heart rhythm
- Suicide 4,408
- Poisoning 3,113
- Tiredness 2,665
- Feeling sick to your stomach 2,309
- Headache 2,218
- The medicine is interacting with another medicine 1,663
- A rare, life-threatening reaction to the drug 1,577
- Weight gain 1,216
- Movement problems 1,200
- Poisoning from different substances 999
Antidepressants may increase the risk of suicidal thoughts and behaviors in children, teenagers, and young adults. Watch closely for worsening depression or suicidal thoughts. Tell your doctor right away if you notice any changes in mood or behavior.
Haloperidol may increase the risk of death in elderly patients with dementia-related psychosis. Haloperidol is not approved to treat dementia-related psychosis.
Talk to your doctor if you are pregnant or plan to become pregnant. It is important to consider the risks of untreated depression during pregnancy. There is a pregnancy registry to monitor outcomes in women exposed to antidepressants during pregnancy. You can register by calling 1-844-405-6185.
Tell your doctor if you are pregnant or plan to become pregnant. Haloperidol may cause side effects in newborns if taken during pregnancy. Talk to your doctor about the risks and benefits of taking haloperidol while breastfeeding.
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How to Read This bupropion vs haloperidol Comparison
bupropion is classified in the Norepinephrine-Dopamine Reuptake Inhibitor (NDRI) drug class, while haloperidol sits within the Typical Antipsychotic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, bupropion has 14,713 submissions while haloperidol has 6,655. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to bupropion stops a liver enzyme from breaking down haloperidol, which can cause haloperidol levels to build up in your body.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between bupropion and haloperidol - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.