bempedoic acid vs bempedoic acid/ezetimibe
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Side-by-side comparison of bempedoic acid and bempedoic acid/ezetimibe. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
7 DRUG INTERACTIONS No specific pharmacokinetic drug interaction studies with NEXLIZET have been conducted. Table 4 lists drug interactions with NEXLIZET that have been identified in studies with bempedoic acid or ezetimibe. Clinically Important Drug Interactions with NEXLIZET Simvastatin Clinical Impact: Concomitant use of NEXLIZET with simvastatin causes an increase in simvastatin concentration and may increase the risk of simvastatin-related myopathy [see Clinical Pharmacology (12.3) ] .
Nexletol
Nexlizet
No summary available.
Nexlizet is a combination medicine that helps lower cholesterol. It is used with diet and exercise to lower LDL-C (bad cholesterol) in adults.
Information not available.
Nexlizet is used to lower LDL-C (bad cholesterol) in adults who have high cholesterol. This includes people with a genetic condition called heterozygous familial hypercholesterolemia (HeFH). One of the medicines in Nexlizet can also lower the risk of heart problems like heart attack and stroke in adults who are at high risk and cannot take statins.
Information not available.
Nexlizet contains two medicines that work in different ways to lower cholesterol. Bempedoic acid blocks an enzyme in your liver that makes cholesterol. Ezetimibe stops your body from absorbing cholesterol from food.
- • Upper respiratory tract infection
- • Muscle spasms
- • High uric acid levels in the blood
- • Back pain
- • Stomach pain or discomfort
- • Upper respiratory tract infection (like a cold)
- • Muscle spasms
- • High uric acid levels in the blood
- • Back pain
- • Stomach pain or discomfort
- Myalgia 335
- Arthralgia 214
- Muscle Spasms 153
- Pain In Extremity 135
- Nausea 130
- Muscle pain 53
- Joint pain 51
- Pain in your arms or legs 40
- Muscle spasms 32
- Tiredness 30
No specific warnings noted.
This medicine can raise uric acid levels in your blood, which can cause gout. Tell your doctor if you have symptoms of high uric acid, like joint pain or swelling. Nexlizet can also increase your risk of tendon rupture. Stop taking Nexlizet and call your doctor right away if you have tendon pain, swelling, or difficulty moving.
No pregnancy information available.
This medicine may harm your unborn baby. Do not take Nexlizet if you are pregnant or planning to become pregnant. Talk to your doctor about other ways to lower your cholesterol during pregnancy.
How to Read This bempedoic acid vs bempedoic acid/ezetimibe Comparison
bempedoic acid is classified in the ACL Inhibitor drug class, while bempedoic acid/ezetimibe sits within the ACL Inhibitor / Cholesterol Absorption Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, bempedoic acid has 967 submissions while bempedoic acid/ezetimibe has 206. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to this combination can cause simvastatin levels to build up in your body, which increases the risk of muscle damage.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for bempedoic acid or bempedoic acid/ezetimibe.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.