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atomoxetine vs diazepam

Side-by-side comparison of atomoxetine and diazepam. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.

minor Known Drug Interaction

Atomoxetine did not affect the binding of warfarin, acetylsalicylic acid, phenytoin, or diazepam to human albumin.

Recommendation: You can safely take these medications together without needing to change your dose.

Drug Class
atomoxetine Selective Norepinephrine Reuptake Inhibitor
diazepam Benzodiazepine
Type
atomoxetine Prescription
diazepam Prescription
Summary
atomoxetine

Atomoxetine (Strattera) is a medicine that can help people with Attention-Deficit/Hyperactivity Disorder (ADHD). It works by affecting a chemical in the brain called norepinephrine.

diazepam

Diazepam (Valium) is a medicine that can help with anxiety, muscle spasms, and seizures. It belongs to a class of drugs called benzodiazepines, which work by slowing down the brain.

What It Treats
atomoxetine

Atomoxetine is used to treat Attention-Deficit/Hyperactivity Disorder (ADHD). ADHD can cause you to be hyperactive, impulsive, and have trouble paying attention. This medicine can help you focus, be less impulsive, and feel calmer. It is for both kids and adults.

diazepam

Diazepam can help manage anxiety disorders or provide short-term relief from anxiety symptoms. It can also relieve symptoms of alcohol withdrawal, such as shaking or agitation. Additionally, diazepam can help with muscle spasms and may be used with other medicines to treat seizures.

How It Works
atomoxetine

Atomoxetine works by increasing the amount of norepinephrine in your brain. Norepinephrine is a chemical that helps you pay attention and control your impulses. By increasing norepinephrine, atomoxetine can improve ADHD symptoms.

diazepam

Diazepam works by increasing the effects of a natural chemical in the brain called GABA. GABA helps to calm the brain and nerves. This can reduce anxiety, relax muscles, and prevent seizures.

Common Side Effects
atomoxetine
  • Feeling sick to your stomach
  • Throwing up
  • Feeling tired
  • Not feeling hungry
  • Belly pain
diazepam
  • Drowsiness
  • Fatigue
  • Muscle weakness
  • Uncoordinated movements
FAERS Reports
atomoxetine
  • Feeling sick to your stomach 431
  • Head pain 407
  • Feeling tired 401
  • The health problem got worse 395
  • High blood pressure 388
diazepam
  • Harm from certain substances 9,167
  • Misuse of medicine 7,019
  • Feeling sick to your stomach 6,144
  • Feeling tired 5,714
  • Discomfort 5,202
Serious Warnings
atomoxetine

Atomoxetine can increase the risk of suicidal thoughts in children and teenagers. Watch carefully for worsening mood or any unusual changes in behavior. Tell your doctor right away if you have any suicidal thoughts or feelings.

diazepam

Diazepam can be habit-forming and can cause serious side effects, including breathing problems, coma, and even death, especially when taken with opioid pain medicines or alcohol. You should not stop taking diazepam suddenly, as this can cause withdrawal symptoms. Talk to your doctor about how to slowly stop taking diazepam.

Pregnancy
atomoxetine

Tell your doctor if you are pregnant or plan to become pregnant. It is not known if atomoxetine will harm your unborn baby. There is a pregnancy registry for women who take ADHD medicines during pregnancy. Talk to your doctor about how to register.

diazepam

Diazepam may harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if diazepam passes into breast milk, so talk to your doctor before breastfeeding.

Also Compare, Nearby Drugs

How to Read This atomoxetine vs diazepam Comparison

atomoxetine is classified in the Selective Norepinephrine Reuptake Inhibitor drug class, while diazepam sits within the Benzodiazepine class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.

Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, atomoxetine has 2,022 submissions while diazepam has 33,246. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to atomoxetine does not change how diazepam binds to proteins in your blood, meaning it does not affect the amount of active medicine in your system.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.

A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between atomoxetine and diazepam - always consult your physician or pharmacist first.

Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.