atomoxetine vs celecoxib
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of atomoxetine and celecoxib. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Therefore, there is a potential for an in vivo drug interaction with drugs that are metabolized by CYP2D6 (e.g., atomoxetine), and celecoxib may enhance the exposure and toxicity of these drugs.
Strattera
Celebrex
Atomoxetine (Strattera) is a medicine that can help people with Attention-Deficit/Hyperactivity Disorder (ADHD). It works by affecting a chemical in the brain called norepinephrine.
Celecoxib (Celebrex) is a medicine that reduces pain and swelling. It belongs to a class of drugs called NSAIDs.
Atomoxetine is used to treat Attention-Deficit/Hyperactivity Disorder (ADHD). ADHD can cause you to be hyperactive, impulsive, and have trouble paying attention. This medicine can help you focus, be less impulsive, and feel calmer. It is for both kids and adults.
Celecoxib treats the symptoms of osteoarthritis and rheumatoid arthritis. It can also help with juvenile rheumatoid arthritis in children 2 years and older. Additionally, it is used for ankylosing spondylitis, acute pain, and menstrual pain.
Atomoxetine works by increasing the amount of norepinephrine in your brain. Norepinephrine is a chemical that helps you pay attention and control your impulses. By increasing norepinephrine, atomoxetine can improve ADHD symptoms.
Celecoxib blocks a substance in the body that causes pain and swelling. It targets COX-2, an enzyme involved in inflammation. By blocking COX-2, celecoxib reduces inflammation and relieves pain.
- • Feeling sick to your stomach
- • Throwing up
- • Feeling tired
- • Not feeling hungry
- • Belly pain
- • Abdominal pain
- • Diarrhea
- • Upset stomach
- • Gas
- • Swelling in your legs or feet
- Nausea 431
- Headache 407
- Fatigue 401
- Condition Aggravated 395
- Hypertension 388
- Pain 12,294
- Arthralgia 10,923
- Fatigue 9,710
- Nausea 9,389
- Drug Hypersensitivity 7,713
Atomoxetine can increase the risk of suicidal thoughts in children and teenagers. Watch carefully for worsening mood or any unusual changes in behavior. Tell your doctor right away if you have any suicidal thoughts or feelings.
Celecoxib may increase your risk of serious heart problems like heart attack and stroke, which can be fatal. This risk may happen early in treatment and increases with longer use. You should not take celecoxib if you are having heart bypass surgery. Celecoxib can also increase the risk of serious stomach and intestine problems like bleeding, ulcers, and holes, which can be fatal. These problems can happen without warning. The elderly and those with a history of ulcers or GI bleeding are at higher risk.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if atomoxetine will harm your unborn baby. There is a pregnancy registry for women who take ADHD medicines during pregnancy. Talk to your doctor about how to register.
Using celecoxib after about 20 weeks of pregnancy can cause kidney problems in the baby and low amniotic fluid. Avoid using celecoxib after 30 weeks of pregnancy because it can cause the baby's heart to close too early. If you are trying to get pregnant, talk to your doctor, as celecoxib may affect fertility.
How to Read This atomoxetine vs celecoxib Comparison
atomoxetine is classified in the Selective Norepinephrine Reuptake Inhibitor drug class, while celecoxib sits within the COX-2 Selective NSAID class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, atomoxetine has 2,022 submissions while celecoxib has 50,029. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to celecoxib can interfere with how your body processes atomoxetine, which may cause the drug to reach toxic levels.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for atomoxetine or celecoxib.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.