aspirin vs tadalafil
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Side-by-side comparison of aspirin and tadalafil. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7.3 Potential for Tadalafil Tablets to Affect Other Drugs Aspirin — Tadalafil did not potentiate the increase in bleeding time caused by aspirin.
Aspirin is a common medicine used to relieve minor pain. It can also be prescribed by your doctor for other uses.
Tadalafil (Cialis) is a medicine that helps men with erectile dysfunction (ED) or enlarged prostate (BPH). It belongs to a class of drugs called PDE5 inhibitors.
Aspirin is used to temporarily relieve minor aches and pains. However, it works slowly. It will not quickly relieve headaches or other symptoms that need immediate relief. Ask your doctor about other uses for this medicine.
This medicine can help men who have trouble getting or keeping an erection (ED). It can also treat the symptoms of an enlarged prostate, also known as benign prostatic hyperplasia (BPH). BPH can cause difficulty with urination.
Aspirin belongs to a class of drugs called NSAIDs and antiplatelets. It works by reducing substances in the body that cause pain and inflammation. It also helps to prevent blood clots.
Tadalafil works by relaxing the muscles in the penis and prostate. This increases blood flow to these areas. For BPH, it relaxes muscles in the prostate and bladder, which can improve urinary symptoms.
- • Upset stomach
- • Heartburn
- • Headache
- • Upset stomach
- • Back pain
- • Muscle aches
- • Nasal congestion
- Fatigue 31,963
- Dyspnoea 27,179
- Nausea 26,579
- Diarrhoea 26,452
- Dizziness 22,390
- Dyspnoea 11,663
- Headache 10,690
- Diarrhoea 7,799
- Nausea 6,498
- Death 5,899
No specific warnings noted.
If you have chest pain, tell your doctor. If you need nitrates for a heart problem, wait 48 hours after taking tadalafil before taking nitrates. If you get an erection that lasts more than 4 hours, get medical help right away. If you have sudden vision loss in one or both eyes, stop taking this medicine and get medical help right away. If you have a sudden decrease or loss of hearing, stop taking this medicine and get medical help right away.
Ask your doctor for advice if you are pregnant or breastfeeding.
This medicine is not for use in women. It is not known if this medicine will harm an unborn baby. It is also not known if this medicine passes into breast milk.
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How to Read This aspirin vs tadalafil Comparison
aspirin is classified in the Antiplatelet / NSAID drug class, while tadalafil sits within the PDE5 Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, aspirin has 134,563 submissions while tadalafil has 42,549. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to tadalafil does not increase the risk of bleeding or change how aspirin affects the blood's ability to clot.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for aspirin or tadalafil.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.