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amikacin vs erythromycin

Side-by-side comparison of amikacin and erythromycin Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.

Drug Class
amikacin Aminoglycoside Antibiotic
erythromycin Macrolide Antibiotic
Type
amikacin Prescription
erythromycin Prescription
Summary
amikacin

Amikacin is an antibiotic medicine. It fights serious infections caused by certain types of bacteria.

erythromycin

Erythromycin Topical Solution is a medicine that you put on your skin to treat acne. It contains an antibiotic to help clear up your skin.

What It Treats
amikacin

Amikacin treats serious infections caused by bacteria. This includes infections in the blood, lungs, bones, joints, brain, skin, and abdomen. It can also treat burns, post-surgery infections, and complicated urinary tract infections.

erythromycin

Erythromycin Topical Solution treats acne vulgaris. This medicine helps to reduce acne on your face, neck, shoulders, chest, and back. It works by fighting the bacteria that cause acne.

How It Works
amikacin

Amikacin belongs to a class of drugs called aminoglycosides. It works by stopping the growth of bacteria. This helps your body fight off the infection.

erythromycin

Erythromycin is a macrolide antibiotic. It works by stopping the growth of bacteria. This helps to reduce inflammation and clear up acne.

Common Side Effects
amikacin

No common side effects listed.

erythromycin
  • Peeling
  • Dryness
  • Itching
  • Redness
  • Oily skin
FAERS Reports
amikacin
  • Off Label Use 1,908
  • Drug Ineffective 1,673
  • Cough 1,620
  • Dyspnoea 1,556
  • Hospitalisation 1,360
erythromycin
  • Drug Hypersensitivity 4,088
  • Nausea 1,271
  • Vomiting 1,121
  • Diarrhoea 1,069
  • Drug Ineffective 1,044
Serious Warnings
amikacin

Amikacin can potentially cause hearing loss and kidney damage. Tell your doctor if you have kidney problems or are taking other medicines that can affect your hearing or kidneys. Your doctor should closely monitor you for hearing and kidney problems during treatment. This drug can also cause muscle weakness or breathing problems, especially if you are also taking anesthesia or certain muscle relaxants.

erythromycin

You should not use this medicine if you are allergic to any of its ingredients.

Pregnancy
amikacin

Tell your doctor if you are pregnant or breastfeeding. Amikacin may harm your unborn baby. It is not known if amikacin passes into breast milk.

erythromycin

It is not known if erythromycin topical solution can harm an unborn baby. Talk to your doctor if you are pregnant or breastfeeding.

Also Compare — Nearby Drugs

How to Read This amikacin vs erythromycin Comparison

amikacin is classified in the Aminoglycoside Antibiotic drug class, while erythromycin sits within the Macrolide Antibiotic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.

Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, amikacin has 8,117 submissions while erythromycin has 8,593. Those figures reflect cumulative reporting volume — not per-patient risk — so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.

A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between amikacin and erythromycin — always consult your physician or pharmacist first.

Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.