aliskiren vs candesartan
Side-by-side comparison of aliskiren and candesartan. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
7.4 Combination Blockade of the Renin-Angiotensin System (RAS) Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of hypotension, hyperkalemia, and changes in renal function (including acute renal failure) compared to monotherapy. Do not co-administer aliskiren with candesartan cilexetil in patients with diabetes. Avoid use of aliskiren with candesartan cilexetil in patients with renal impairment (GFR <60 ml/min) [see Contraindications (4)].
Recommendation: Avoid this combination, especially if you have diabetes or kidney issues. Your doctor should monitor your kidney function and blood pressure closely.
Tekturna
Atacand
Tekturna is a medicine used to treat high blood pressure. It helps lower blood pressure, which can reduce the risk of strokes and heart attacks.
Candesartan is a medicine that lowers blood pressure. It can also help treat heart failure.
Tekturna is used to treat high blood pressure in adults and children who weigh at least 110 pounds and are 6 years or older. Lowering your blood pressure helps prevent strokes and heart attacks. It is important to manage high blood pressure with a healthy lifestyle too.
Candesartan is used to treat high blood pressure in adults and children ages 1 to 17. Lowering blood pressure reduces the risk of strokes and heart attacks. Candesartan also treats heart failure by reducing the risk of death and hospitalization.
Tekturna works by blocking a substance in your body called renin. Renin helps to control your blood pressure. By blocking renin, Tekturna helps to lower your blood pressure.
Candesartan blocks a substance in your body that tightens blood vessels. This helps blood vessels relax and widens them. As a result, blood pressure is lowered and the heart can pump blood more easily.
- • Diarrhea
- • Dizziness
- • Upper respiratory tract infection
- • Back pain
- • Pharyngitis (sore throat)
- • Rhinitis (runny nose)
- Weakness 367
- Fall 356
- Feeling sick to your stomach 336
- Shortness of breath 314
- Headache 301
- Shortness of breath 3,169
- Tiredness 3,158
- Feeling sick to your stomach 2,989
- Loose stools 2,764
- Feeling lightheaded 2,677
Tekturna can harm your unborn baby, even causing death. If you become pregnant, stop taking Tekturna right away and tell your doctor.
If you are pregnant or plan to become pregnant, stop taking this medicine right away. Candesartan can harm or cause death to your unborn baby.
Tekturna can cause serious harm or death to an unborn baby. If you are pregnant or plan to become pregnant, talk to your doctor about other blood pressure medicines. Breastfeeding is not recommended while taking Tekturna.
Candesartan can cause serious harm to an unborn baby, especially during the second and third trimesters. If you are breastfeeding, talk to your doctor about whether to stop breastfeeding or stop taking this medicine.
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How to Read This aliskiren vs candesartan Comparison
aliskiren is classified in the Direct Renin Inhibitor drug class, while candesartan sits within the Angiotensin II Receptor Blocker (ARB) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, aliskiren has 1,674 submissions while candesartan has 14,757. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to both drugs work on the same system to lower blood pressure, which can lead to severe kidney problems and high potassium levels. this double-blocking effect makes side effects much more likely than taking just one drug.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between aliskiren and candesartan - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.