aflibercept vs cyclosporine ophthalmic
Side-by-side comparison of aflibercept and cyclosporine ophthalmic Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Eylea
Restasis, Cequa
AHZANTIVE is a medicine used to treat certain eye problems. It helps to stop blood vessels from growing and leaking in the eye.
VEVYE eye drops contain cyclosporine. They help treat the signs and symptoms of dry eye disease.
AHZANTIVE treats wet age-related macular degeneration (AMD). It also treats swelling in the macula (the central part of the retina) caused by retinal vein occlusion (RVO) or diabetic macular edema (DME). Additionally, it can treat diabetic retinopathy (DR), an eye disease caused by diabetes.
VEVYE treats dry eye disease. Dry eye can cause discomfort and vision problems. This medicine helps relieve the signs and symptoms of dry eye.
AHZANTIVE is a VEGF inhibitor. VEGF is a protein that promotes the growth of new blood vessels. By blocking VEGF, AHZANTIVE helps to reduce the growth of abnormal blood vessels in the eye and decrease leakage.
VEVYE contains cyclosporine, which is a type of medicine that lowers your body's immune response in the eye. It reduces inflammation. This helps your eyes make more tears.
- • Bleeding in the eye
- • Eye pain
- • Clouding of the lens of the eye (cataract)
- • Separation of the vitreous gel from the retina
- • Spots in your vision
- • Irritation where the drop is applied
- Death 7,853
- Trouble seeing 2,013
- Using the medicine for something it's not approved for 1,509
- Loss of sight 1,459
- Eye infection 1,372
No adverse event reports.
Injections with AHZANTIVE may cause serious eye infections (endophthalmitis), separation of the retina (retinal detachment), and inflammation of blood vessels in the retina. Tell your doctor right away if you have any signs of these problems. AHZANTIVE may also increase the risk of blood clots that can cause stroke or heart attack.
To avoid injury or contamination, do not touch your eye or other surfaces with the bottle tip. Do not use VEVYE while wearing contact lenses. If you wear contacts, take them out before using the drops. You can put them back in 15 minutes after using the drops.
It is not known if AHZANTIVE can harm an unborn baby. AHZANTIVE should be used during pregnancy only if the benefit justifies the risk. It is also not known if AHZANTIVE passes into breast milk.
It is not known if VEVYE can harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is also not known if VEVYE passes into breast milk, so talk to your doctor if you are breastfeeding.
Also Compare — Nearby Drugs
Compare aflibercept with
How to Read This aflibercept vs cyclosporine ophthalmic Comparison
aflibercept is classified in the Anti-VEGF (Ophthalmic Injection) drug class, while cyclosporine ophthalmic sits within the Immunosuppressant (Ophthalmic) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, aflibercept has 14,206 submissions while cyclosporine ophthalmic has 0. Those figures reflect cumulative reporting volume — not per-patient risk — so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between aflibercept and cyclosporine ophthalmic — always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.