acebutolol vs metoprolol
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of acebutolol and metoprolol. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Sectral
Lopressor, Toprol-XL
Acebutolol is a medicine that helps lower blood pressure and control irregular heartbeats. It belongs to a class of drugs called beta-blockers.
Metoprolol is a beta-blocker medicine. It can lower blood pressure, reduce chest pain, and improve survival after a heart attack.
Acebutolol is used to treat high blood pressure in adults. It can be used alone or with other blood pressure medicines. Acebutolol is also used to manage irregular heartbeats called ventricular arrhythmias. It helps to reduce the number of these irregular beats.
Metoprolol treats high blood pressure (hypertension). Lowering blood pressure reduces the risk of strokes and heart attacks. It also treats chest pain called angina. After a heart attack, it can help you live longer.
Acebutolol works by blocking the effects of certain natural chemicals in your body, like adrenaline, on the heart and blood vessels. This helps to slow down the heart rate and lower blood pressure. It also helps to make the heart beat more regularly.
Metoprolol blocks the effects of adrenaline on the heart. This makes the heart beat slower and with less force. As a result, blood pressure is lowered and the heart does not need as much oxygen.
No common side effects listed.
- • Tiredness
- • Dizziness
- • Depression
- • Shortness of breath
- • Slow heart rate
- Cognitive Disorder 620
- Fall 615
- Orthostatic Hypotension 573
- Balance Disorder 568
- Constipation 565
- Fatigue 15,966
- Dyspnoea 14,128
- Diarrhoea 13,635
- Nausea 13,398
- Dizziness 11,699
You should not take acebutolol if you have a very slow heart rate, second- or third-degree heart block, heart failure, or cardiogenic shock.
Stopping metoprolol suddenly can make chest pain worse or cause a heart attack. If you have heart failure, it could get worse. If you have asthma or other lung problems, avoid beta-blockers if possible.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if acebutolol will harm an unborn baby. Talk to your doctor about the risks and benefits of taking acebutolol while breastfeeding.
Tell your doctor if you are pregnant or plan to become pregnant. Metoprolol can cross the placenta, and may cause low blood pressure, low blood sugar, and a slow heart rate in the newborn. Talk to your doctor about the risks and benefits.
How to Read This acebutolol vs metoprolol Comparison
acebutolol is classified in the Beta-1 Selective Blocker with ISA drug class, while metoprolol sits within the Beta-Blocker class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, acebutolol has 2,941 submissions while metoprolol has 68,826. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for acebutolol or metoprolol.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.