acebutolol vs hydrochlorothiazide/triamterene
Side-by-side comparison of acebutolol and hydrochlorothiazide/triamterene Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Sectral
Dyazide, Maxzide
Acebutolol is a medicine that helps lower blood pressure and control irregular heartbeats. It belongs to a class of drugs called beta-blockers.
This medicine combines lisinopril and hydrochlorothiazide to lower high blood pressure. Lowering blood pressure reduces the risk of strokes and heart attacks.
Acebutolol is used to treat high blood pressure in adults. It can be used alone or with other blood pressure medicines. Acebutolol is also used to manage irregular heartbeats called ventricular arrhythmias. It helps to reduce the number of these irregular beats.
This medicine is used to treat high blood pressure. High blood pressure can lead to serious problems like stroke and heart attack if it is not treated. Lowering your blood pressure can help prevent these problems. You may need more than one medicine to control your blood pressure.
Acebutolol works by blocking the effects of certain natural chemicals in your body, like adrenaline, on the heart and blood vessels. This helps to slow down the heart rate and lower blood pressure. It also helps to make the heart beat more regularly.
Lisinopril is an ACE inhibitor that widens blood vessels. Hydrochlorothiazide is a diuretic that helps your body get rid of extra salt and water. This combination helps to lower blood pressure.
No common side effects listed.
- • Dizziness
- • Headache
- • Cough
- • Feeling tired
- • Lightheadedness when standing up
- Problems with thinking or memory 620
- Falling down 615
- Low blood pressure when standing up 573
- Problems with balance 568
- Difficulty passing stools 565
- Feeling tired 10,013
- Feeling sick to your stomach 9,706
- Medicine not working 9,356
- Loose stools 8,311
- General pain 7,665
You should not take acebutolol if you have a very slow heart rate, second- or third-degree heart block, heart failure, or cardiogenic shock.
This medicine can harm your unborn baby. If you become pregnant, stop taking this medicine and tell your doctor right away. You should not take this medicine if you have ever had a severe allergic reaction (angioedema) to an ACE inhibitor or if you cannot urinate.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if acebutolol will harm an unborn baby. Talk to your doctor about the risks and benefits of taking acebutolol while breastfeeding.
This medicine can cause harm or death to an unborn baby. Do not take this medicine if you are pregnant. Talk to your doctor about other blood pressure medicines if you are breastfeeding.
How to Read This acebutolol vs hydrochlorothiazide/triamterene Comparison
acebutolol is classified in the Beta-1 Selective Blocker with ISA drug class, while hydrochlorothiazide/triamterene sits within the Thiazide / Potassium-Sparing Diuretic Combination class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, acebutolol has 2,941 submissions while hydrochlorothiazide/triamterene has 45,051. Those figures reflect cumulative reporting volume — not per-patient risk — so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between acebutolol and hydrochlorothiazide/triamterene — always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.