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Medicines labeled for the same conditions

Alternatives to rivaroxaban

4 other medicines are given the same way (oral) and in the same FDA class as rivaroxaban or labeled mainly for the same use (atrial fibrillation); 2 are in its class, factor Xa inhibitors: apixaban and edoxaban; the others include 1 vitamin k antagonist and 1 direct thrombin inhibitor (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $5.52 per Eliquis 5 mg tablet (what pharmacies paid in the NADAC survey; strengths differ).

Which medicines are labeled for the same conditions as rivaroxaban?

Atrial fibrillation lists all 17 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.

Medicine and FDA classShared indicationGeneric labelers (oral)Pharmacy costBoxed warningShortage
Rivaroxabanfactor Xa inhibitorthis medicine20 labelers$0.650 per tablet 2.5 mg tabletYesA presentation being discontinued
Apixabanfactor Xa inhibitor · same classAtrial fibrillation, Blood clots (DVT and PE), Stroke prevention2 labelers$5.52 per tablet 5 mg tabletYesNo current entry
Edoxabanfactor Xa inhibitor · same classAtrial fibrillation, Blood clots (DVT and PE), Stroke preventionnone listed$15.51 per tablet 60 mg tabletYesNo current entry
Warfarinvitamin k antagonistAtrial fibrillation, Blood clots (DVT and PE)19 labelers$0.093 per tablet 2 mg tabletYesNo current entry
Dabigatrandirect thrombin inhibitorAtrial fibrillation, Blood clots (DVT and PE), Stroke prevention16 labelers$0.795 per capsule 150 mg capsuleYesNo current entry

Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)

What do pharmacies pay for each?

The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.

Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price

What next?

Rivaroxaban: the full record
label, generics, price, shortages, recalls
Apixaban vs rivaroxaban
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Edoxaban vs rivaroxaban
two records side by side
Rivaroxaban vs warfarin
two records side by side
Dabigatran vs rivaroxaban
two records side by side