Prescription medication · Active Folate (L-methylfolate)
methylfolate
Also sold as Deplin. This medicine is a multivitamin and mineral supplement.
Data updated 2026-05-15
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methylfolate (Deplin) is a prescription Active Folate (L-methylfolate). This medicine is a multivitamin and mineral supplement.
PNV-DHA is a multivitamin with minerals and essential fatty acids. It helps manage nutritional deficiencies and provides extra nutrients.
Verify with FDA → · CMS NADAC pricing →
What it does
This medicine is a multivitamin and mineral supplement.
Common side effects
Allergic reaction (skin rash, itching, hives)
Key warnings
Accidental overdose of iron can cause fatal poisoning in children under 6.
The sections below are summarized in plain English from methylfolate's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.
How It Works
PNV-DHA provides vitamins, minerals, and omega-3 fatty acids. These nutrients help support overall health. They make up for any shortages in your diet.
How to Take It
Take one softgel each day. You can take it before, during, or after pregnancy. Follow your doctor's instructions on how to take this medicine.
This is a plain-language summary of methylfolate's FDA labeling, not individualized dosing advice. Ask a pharmacist or prescriber before changing how you take this medication.
Pregnancy & Breastfeeding
This medicine can be taken before, during, and after pregnancy. Talk to your doctor to see if it is right for you. They can decide if it is safe and helpful for you.
This is a plain-language summary of methylfolate's FDA labeling, not individualized advice. Ask a pharmacist or prescriber about pregnancy or breastfeeding on this medication.
Missed Dose
If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule.
This is a plain-language summary of methylfolate's FDA labeling, not individualized advice. Ask a pharmacist or prescriber what to do about your specific missed dose.
Storage
Store at room temperature, between 68° and 77°F.
Serious Warnings
Accidental overdose of iron can cause fatal poisoning in children under 6. Keep this medicine away from children. If a child swallows too much, call a doctor or poison control center right away.
Common Questions
What is PNV-DHA?
Who should take PNV-DHA?
How often should I take PNV-DHA?
Can I take PNV-DHA if I am allergic to any of the ingredients?
What should I do if a child swallows PNV-DHA?
What does the softgel look like?
Does PNV-DHA contain iron?
Can I take this if I am breastfeeding?
What vitamins are in PNV-DHA?
What minerals are in PNV-DHA?
What are the common side effects of methylfolate?
What drug class is methylfolate?
Is methylfolate safe during pregnancy?
Related Medications in Active Folate (L-methylfolate)
Other drugs grouped near methylfolate - same-class peers and common alternatives.
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calcitriol
Rocaltrol
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calcium carbonate
Tums, Caltrate
Calcium carbonate is a medicine that can relieve heartburn and upset stomach.
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cholecalciferol
Vitamin D3
PNV-DHA is a multivitamin with minerals and essential fatty acids.
Compare with methylfolate →
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What the FDA Data Shows for methylfolate
The FDA label for methylfolate (sold under brand names such as Deplin) classifies it as a prescription-only medication in the Active Folate (L-methylfolate) class. This medicine is a multivitamin and mineral supplement. Official labeling lists 1 commonly reported side effect, including Allergic reaction (skin rash, itching, hives).
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. Voluntary reports accumulate over the lifetime of a drug and reflect wide-ranging clinical use. Interaction data is drawn directly from FDA-approved prescribing information. Acquisition-cost data is surveyed weekly by CMS and updated as manufacturers report changes.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice, always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: January 15, 2024
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled and last refreshed May 2026. See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a correction.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages