Medicines labeled for the same conditions

Alternatives to guanfacine

11 other medicines are given the same way (oral) and in the same FDA class as guanfacine or labeled mainly for the same use (ADHD); 1 is in its class, central alpha-2 adrenergic agonists: clonidine; the others include 7 central nervous system stimulants, 2 norepinephrine reuptake inhibitors and 1 amphetamine anorectic (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $0.0241 per clonidine HCl 0.1 mg tablet (what pharmacies paid in the NADAC survey; strengths differ).

Which medicines are labeled for the same conditions as guanfacine?

ADHD lists all 12 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.

Medicine and FDA class	Shared indication	Generic labelers (oral)	Pharmacy cost	Boxed warning	Shortage
Guanfacinecentral alpha-2 adrenergic agonist	this medicine	37 labelers	$0.147 per tablet 1 mg tablet	No	A presentation being discontinued
Clonidinecentral alpha-2 adrenergic agonist · same class	High blood pressure, ADHD	37 labelers	$0.0241 per tablet 0.1 mg tablet	No	No current entry
Methylphenidatecentral nervous system stimulant	ADHD	31 labelers	$0.158 per tablet 10 mg tablet	Yes	In shortage
Amphetamine and dextroamphetaminecentral nervous system stimulant	ADHD	25 labelers	$0.233 per tablet 10 mg tablet	Yes	In shortage
Lisdexamfetaminecentral nervous system stimulant	ADHD	19 labelers	$2.44 per capsule 20 mg capsule	Yes	In shortage
Atomoxetinenorepinephrine reuptake inhibitor	ADHD	20 labelers	$0.442 per capsule 40 mg capsule	Yes	No current entry
Dexmethylphenidatecentral nervous system stimulant	ADHD	13 labelers	$1.45 per capsule 10 mg capsule	Yes	No current entry
Amphetaminecentral nervous system stimulant	ADHD	13 labelers	$0.449 per tablet 10 mg tablet	Yes	No current entry
Dextroamphetaminecentral nervous system stimulant	ADHD	14 labelers	$0.373 per tablet 10 mg tablet	Yes	No current entry
Dexmethylphenidate and serdexmethylphenidatecentral nervous system stimulant	ADHD	none listed	$14.40 per capsule 26.1 mg-5.2 mg capsule	Yes	No current entry
Methamphetamineamphetamine anorectic	ADHD	3 labelers	$5.10 per tablet 5 mg tablet	Yes	No current entry
Viloxazinenorepinephrine reuptake inhibitor	ADHD	none listed	$12.74 per capsule 200 mg capsule	Yes	No current entry

Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)

What do pharmacies pay for each?

The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.

Clonidine$0.0241
Methylphenidate$0.158
Amphetamine and dextroamphetamine$0.233
Dextroamphetamine$0.373
Atomoxetine$0.442
Amphetamine$0.449
Dexmethylphenidate$1.45
Lisdexamfetamine$2.44
Methamphetamine$5.10
Viloxazine$12.74
Dexmethylphenidate and serdexmethylphenidate$14.40

Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price

What next?

Guanfacine: the full record: label, generics, price, shortages, recalls
Clonidine vs guanfacine: two records side by side
Guanfacine vs methylphenidate: two records side by side
Atomoxetine vs guanfacine: two records side by side
Guanfacine vs dextroamphetamine: two records side by side