Medicines labeled for the same conditions
Alternatives to duloxetine
31 other medicines are given the same way (oral) and in the same FDA class as duloxetine or labeled mainly for the same use (depression); 4 are in its class, serotonin and norepinephrine reuptake inhibitors: venlafaxine, desvenlafaxine, milnacipran and levomilnacipran; the others include 8 serotonin reuptake inhibitors, 8 tricyclic antidepressants and 2 aminoketones (FDA labels read October 8, 2026). In the same class, the lowest pharmacy cost is $0.0799 per venlafaxine HCl ER 75 mg capsule (what pharmacies paid in the NADAC survey; strengths differ).
Which medicines are labeled for the same conditions as duloxetine?
The first 24 of the 31, the same class first. Depression lists all 37 medicines labeled for it, by any route. Each row shows the conditions both labels name. They are listed as public records, not as substitutes: whether one can replace another depends on the person and is a prescriber's decision.
| Medicine and FDA class | Shared indication | Generic labelers (oral) | Pharmacy cost | Boxed warning | Shortage |
|---|---|---|---|---|---|
| Duloxetineserotonin and norepinephrine reuptake inhibitor | this medicine | 45 labelers | $0.102 per capsule 30 mg capsule | Yes | No current entry |
| Venlafaxineserotonin and norepinephrine reuptake inhibitor · same class | Depression, Anxiety | 62 labelers | $0.0799 per capsule 75 mg capsule | Yes | No current entry |
| Desvenlafaxineserotonin and norepinephrine reuptake inhibitor · same class | Depression | 21 labelers | $0.396 per unit 50 mg | Yes | No current entry |
| Milnacipranserotonin and norepinephrine reuptake inhibitor · same class | Nerve pain and fibromyalgia | 4 labelers | $2.82 per tablet 100 mg tablet | Yes | No current entry |
| Levomilnacipranserotonin and norepinephrine reuptake inhibitor · same class | Depression | none listed | $17.61 per unit 20-40 mg titration pak | Yes | No current entry |
| Bupropionaminoketone | Depression | 73 labelers | $0.0785 per tablet 150 mg tablet | Yes | No current entry |
| Aripiprazoleatypical antipsychotic | Depression | 47 labelers | $0.110 per tablet 5 mg tablet | Yes | No current entry |
| Fluoxetineserotonin reuptake inhibitor | Depression, Anxiety | 59 labelers | $0.0519 per capsule 40 mg capsule | Yes | No current entry |
| Sertralineserotonin reuptake inhibitor | Depression, Anxiety | 48 labelers | $0.0507 per tablet 100 mg tablet | Yes | No current entry |
| Amitriptylinetricyclic antidepressant | Depression | 36 labelers | $0.03 per tablet 10 mg tablet | Yes | No current entry |
| Doxepintricyclic antidepressant | Depression, Anxiety | 48 labelers | $0.0779 per capsule 10 mg capsule | Yes | No current entry |
| Paroxetineserotonin reuptake inhibitor | Depression, Anxiety | 45 labelers | $0.0611 per tablet 20 mg tablet | Yes | No current entry |
| Trazodoneserotonin reuptake inhibitor | Depression | 38 labelers | $0.0307 per tablet 50 mg tablet | Yes | No current entry |
| Escitalopramserotonin reuptake inhibitor | Depression, Anxiety | 44 labelers | $0.0632 per tablet 20 mg tablet | Yes | No current entry |
| Mirtazapine | Depression | 36 labelers | $0.063 per tablet 15 mg tablet | Yes | No current entry |
| Citalopramserotonin reuptake inhibitor | Depression | 35 labelers | $0.026 per tablet 10 mg tablet | Yes | No current entry |
| Nortriptylinetricyclic antidepressant | Depression | 27 labelers | $0.113 per capsule 10 mg capsule | Yes | No current entry |
| Desipraminetricyclic antidepressant | Depression | 9 labelers | $0.276 per tablet 75 mg tablet | Yes | No current entry |
| Imipraminetricyclic antidepressant | Depression | 14 labelers | $0.0698 per tablet 10 mg tablet | Yes | No current entry |
| Vilazodone | Depression | 12 labelers | $0.732 per tablet 10 mg tablet | Yes | No current entry |
| Fluoxetine and olanzapineserotonin reuptake inhibitor | Depression | 3 labelers | $3.44 per unit 3-25 mg | Yes | No current entry |
| Brexpiprazoleatypical antipsychotic | Depression | 1 labeler | $49.50 per tablet 0.25 mg tablet | Yes | No current entry |
| Trimipraminetricyclic antidepressant | Depression | 3 labelers | n/a | Yes | No current entry |
| Amoxapinetricyclic antidepressant | Depression, Anxiety | 2 labelers | n/a | Yes | No current entry |
| Vortioxetine | Depression | none listed | $17.20 per tablet 10 mg tablet | Yes | No current entry |
Source: FDA drug labels (indications) via openFDA; FDA NDC Directory; CMS NADAC of October 7, 2026; FDA Drug Shortage Database (FDA files October 8, 2026)
What do pharmacies pay for each?
The headline NADAC price per unit of each medicine's most widely listed form; strengths differ, so compare like with like on each record.
Source: CMS National Average Drug Acquisition Cost (NADAC) survey, October 7, 2026: what retail pharmacies paid per unit; not a counter price
What next?
- Duloxetine: the full record
- label, generics, price, shortages, recalls
- Duloxetine vs venlafaxine
- two records side by side
- Desvenlafaxine vs duloxetine
- two records side by side
- Duloxetine vs milnacipran
- two records side by side
- Bupropion vs duloxetine
- two records side by side