Alternatives to duloxetine
3 same-class SPL records vs duloxetine - uses, FAERS reaction fields, and OTC/Rx flags from public FDA sources.
Brand: Cymbalta
How to read a high-report FAERS peer set
duloxetine ranks in the upper FAERS-volume third of the corpus (#111 of 524); 3 same-class peers are listed for field comparison only. Labeled indication field for duloxetine: Duloxetine can treat major depressive disorder and generalized anxiety disorder in adults and children (7 years and older).
Top FAERS reaction fields for duloxetine total 33,143 reports across 10 reactions, set beside desvenlafaxine, levomilnacipran, venlafaxine. Counts are exposure-weighted submissions, not per-patient risk.
About duloxetine
Duloxetine is a medicine that can help treat depression and anxiety. It can also help with certain types of pain.
Used for: Duloxetine can treat major depressive disorder and generalized anxiety disorder in adults and children (7 years and older). It can also treat diabetic nerve pain, fibromyalgia, and chronic muscle or bone pain in adults. In children, it can treat fibromyalgia (13 years and older).
3 Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) peers (wide set)
desvenlafaxine
RxPristiq
Pristiq is used to treat major depressive disorder (MDD) in adults. MDD can cause you to feel sad, lose interest in activities, and have trouble with daily life. This medicine can help improve your mood and energy levels.
levomilnacipran
RxFetzima
Fetzima is used to treat major depressive disorder (MDD) in adults. MDD can cause you to feel sad, lose interest in activities, and have trouble with daily life. Fetzima can help improve your mood and reduce these symptoms.
venlafaxine
RxEffexor, Effexor XR
Venlafaxine is used to treat major depressive disorder. This condition can cause a persistent feeling of sadness or loss of interest in daily activities. It may also help maintain improvement in patients with recurrent depression.
duloxetine vs desvenlafaxine & levomilnacipran · FAERS reaction fields
FAERS top-reaction field "Pain" shows the widest count spread between duloxetine and desvenlafaxine, levomilnacipran, venlafaxine in this extract (1,107-report gap on that field). Counts are exposure-weighted submissions, not prevalence rates.
| Side Effect | duloxetine | desvenlafaxine | levomilnacipran | venlafaxine |
|---|---|---|---|---|
| Fatigue | 4,787 | 166 | - | 4,198 |
| Nausea | 4,782 | 206 | 143 | 4,298 |
| Pain | 3,697 | 117 | 210 | 2,590 |
| Headache | 3,654 | 159 | 112 | 3,740 |
| Diarrhoea | 3,262 | 94 | - | 2,786 |
| Dizziness | 3,034 | 133 | 106 | 3,026 |
| Fall | 2,784 | - | - | 2,373 |
| Vomiting | 2,456 | - | 208 | 2,421 |
"-" means no reports for that reaction. Report counts reflect total FAERS submissions, not prevalence rates.
duloxetine FAERS volume vs class peers
FAERS volume band
duloxetine is FAERS corpus rank #111 of 524 (high volume tercile). Top-reaction field total: 33,143.
Frequently Asked Questions
Where does duloxetine sit in FAERS report volume vs Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) peers? ▼
Registry note: FAERS counts are voluntary reports and do not establish causation or risk rates. This information is for educational purposes only and is not a substitute for professional medical advice. Do not stop or change your medication without talking to your doctor or pharmacist.
Field note for duloxetine: see also the generic vs brand label guide when reading Cymbalta SPL strings.
Read our methodology - how this data is sourced, computed, and verified.