Prescription medication · ACL Inhibitor / Cholesterol Absorption Inhibitor

bempedoic acid/ezetimibe

Name: bempedoic acid/ezetimibe - FDA Drug Safety & Adverse Event Data
Creator: PlainMeds
License: https://creativecommons.org/publicdomain/zero/1.0/

Also sold as Nexlizet. Nexlizet is used to lower LDL-C (bad cholesterol) in adults who have high cholesterol.

Compiled by PlainMeds Editorial, Drug Information Editorial Team

Data updated 2026-05-15

329
FDA reports: 7
InteractionsFew interactions: $13.05
Brand price (NADAC)

What the data shows

bempedoic acid/ezetimibe (Nexlizet) is a prescription ACL Inhibitor / Cholesterol Absorption Inhibitor, with 329 FDA adverse-event reports on file, with 7 documented drug interactions.

Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.

bempedoic acid/ezetimibe (Nexlizet) is a prescription ACL Inhibitor / Cholesterol Absorption Inhibitor. Nexlizet is used to lower LDL-C (bad cholesterol) in adults who have high cholesterol.

Nexlizet is a combination medicine that helps lower cholesterol. It is used with diet and exercise to lower LDL-C (bad cholesterol) in adults.

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Drug Pricing (NADAC)

Brand Price

$13.05/unit

Generic Available

Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →

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What it does

Nexlizet is used to lower LDL-C (bad cholesterol) in adults who have high cholesterol.

Common side effects

Upper respiratory tract infection (like a cold), Muscle spasms, High uric acid levels in the blood

Key warnings

This medicine can raise uric acid levels in your blood, which can cause gout.

The sections below are summarized in plain English from bempedoic acid/ezetimibe's FDA-approved prescribing information. They describe what the official label says, and are not personal medical advice.

How It Works

Nexlizet contains two medicines that work in different ways to lower cholesterol. Bempedoic acid blocks an enzyme in your liver that makes cholesterol. Ezetimibe stops your body from absorbing cholesterol from food.

How to Take It

Take one Nexlizet tablet each day. You can take it with or without food. Swallow the tablet whole with a glass of water. If you miss a dose, take it as soon as you remember. But do not take two doses at the same time.

This is a plain-language summary of bempedoic acid/ezetimibe's FDA labeling, not individualized dosing advice. Ask a pharmacist or prescriber before changing how you take this medication.

Pregnancy & Breastfeeding

This medicine may harm your unborn baby. Do not take Nexlizet if you are pregnant or planning to become pregnant. Talk to your doctor about other ways to lower your cholesterol during pregnancy.

This is a plain-language summary of bempedoic acid/ezetimibe's FDA labeling, not individualized advice. Ask a pharmacist or prescriber about pregnancy or breastfeeding on this medication.

Missed Dose

If you miss a dose, take it as soon as you remember. Do not take two doses at the same time to make up for the missed dose.

This is a plain-language summary of bempedoic acid/ezetimibe's FDA labeling, not individualized advice. Ask a pharmacist or prescriber what to do about your specific missed dose.

Storage

Store Nexlizet at room temperature, between 68°F to 77°F (20°C to 25°C), in the original package, away from heat and humidity. Keep the desiccant in the bottle.

Side Effects (from patient reports)

Based on 329 FDA adverse event reports.

Muscle pain

53
Joint pain

51
Pain in your arms or legs

40
Muscle spasms

32
Tiredness

30
Back pain

26
Headache

26
Diarrhea

24
Pain

24
Rash

23

What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.

Serious Warnings

This medicine can raise uric acid levels in your blood, which can cause gout. Tell your doctor if you have symptoms of high uric acid, like joint pain or swelling. Nexlizet can also increase your risk of tendon rupture. Stop taking Nexlizet and call your doctor right away if you have tendon pain, swelling, or difficulty moving.

Known Drug Interactions

moderate simvastatin

Clinically Important Drug Interactions with NEXLIZET Simvastatin Clinical Impact: Concomitant use of NEXLIZET with simvastatin causes an increase in simvastatin concentration and may increase the risk of simvastatin-related myopathy [see Clinical Pharmacology (12.3) ] . Intervention: Avoid concomitant use of NEXLIZET with simvastatin greater than 20 mg. Simvastatin: Avoid concomitant use of NEXLIZET with simvastatin greater than 20 mg.

Mechanism: Taking these together can cause simvastatin levels to rise in your body, which may lead to muscle pain or weakness.

What to do: Avoid taking more than 20 mg of simvastatin daily when using this medication.

moderate pravastatin

Pravastatin Clinical Impact: Concomitant use of NEXLIZET with pravastatin causes an increase in pravastatin concentration and may increase the risk of pravastatin-related myopathy [see Clinical Pharmacology (12.3) ] . Intervention: Avoid concomitant use of NEXLIZET with pravastatin greater than 40 mg. ( 7 ) Pravastatin: Avoid concomitant use of NEXLIZET with pravastatin greater than 40 mg.

Mechanism: This medicine can raise the levels of pravastatin in your blood, which may lead to muscle pain or weakness.

What to do: Avoid taking more than 40 mg of pravastatin daily when using this medication.

moderate fenofibrate

Fibrates Clinical Impact: Both fenofibrate and ezetimibe (a component of NEXLIZET) may increase cholesterol excretion into the bile, leading to cholelithiasis. Coadministration of NEXLIZET with fibrates other than fenofibrate is not recommended [see Adverse Reactions (6.1) ] . Intervention: If cholelithiasis is suspected in a patient receiving NEXLIZET and fenofibrate, gallbladder studies are indicated and alternative lipid-lowering therapy should be considered.

Mechanism: Both of these medicines can increase the amount of cholesterol that moves into the bile, which may cause gallstones to form.

What to do: If you suspect you have gallstones, your doctor should perform tests and may consider a different treatment.

moderate bempedoic acid

7 DRUG INTERACTIONS No specific pharmacokinetic drug interaction studies with NEXLIZET have been conducted. Table 4 lists drug interactions with NEXLIZET that have been identified in studies with bempedoic acid or ezetimibe. Clinically Important Drug Interactions with NEXLIZET Simvastatin Clinical Impact: Concomitant use of NEXLIZET with simvastatin causes an increase in simvastatin concentration and may increase the risk of simvastatin-related myopathy [see Clinical Pharmacology (12.3) ] .

Mechanism: This combination can cause simvastatin levels to build up in your body, which increases the risk of muscle damage.

What to do: Your doctor may need to adjust your dose or monitor you closely for muscle pain.

minor ezetimibe

Table 4 lists drug interactions with NEXLIZET that have been identified in studies with bempedoic acid or ezetimibe. Cyclosporine Clinical Impact: Concomitant use of NEXLIZET and cyclosporine increases ezetimibe and cyclosporine concentrations. The degree of increase in ezetimibe exposure may be greater in patients with severe renal insufficiency [see Clinical Pharmacology (12.3) ] .

Mechanism: These medicines increase each other's levels in the body, and this effect can be even stronger if you have severe kidney issues.

What to do: Your doctor should monitor your medicine levels closely, especially if you have poor kidney function.

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This is a plain-language summary of interactions documented in FDA labeling, not individualized advice. Ask a pharmacist or prescriber before combining medications.

Common Questions

What should I do if I experience muscle pain while taking Nexlizet?

Tell your doctor right away if you have muscle pain, tenderness, or weakness, especially if you also have fever or feel tired.

Can I take Nexlizet with other cholesterol-lowering medications?

Nexlizet can be taken with other cholesterol-lowering medications, but talk to your doctor about which medicines are safe to take together.

How often should I have my cholesterol levels checked while taking Nexlizet?

Your doctor will check your cholesterol levels within 8 to 12 weeks after starting Nexlizet.

Can Nexlizet cause liver problems?

Nexlizet can cause elevated liver enzymes. Your doctor may do blood tests to check your liver function.

Is it safe to drink alcohol while taking Nexlizet?

Talk to your doctor about whether it is safe for you to drink alcohol while taking Nexlizet.

What if I have kidney problems?

Tell your doctor if you have kidney problems, as this medicine can sometimes affect kidney function.

Can Nexlizet affect my blood sugar?

Nexlizet is not known to significantly affect blood sugar levels.

Are there any foods I should avoid while taking Nexlizet?

Follow a healthy diet as recommended by your doctor or a registered dietitian.

How long will I need to take Nexlizet?

You may need to take Nexlizet long-term to manage your cholesterol levels. Talk to your doctor.

What if I am taking other medications?

Tell your doctor about all the medicines you take, including prescription and over-the-counter drugs, vitamins, and herbal supplements.

What are the common side effects of bempedoic acid/ezetimibe?

The most commonly reported side effects of bempedoic acid/ezetimibe include Upper respiratory tract infection (like a cold), Muscle spasms, High uric acid levels in the blood, Back pain, Stomach pain or discomfort. Based on 329 FDA adverse event reports. Always consult your healthcare provider about potential side effects.

Does bempedoic acid/ezetimibe interact with other medications?

Yes, bempedoic acid/ezetimibe has 7 known drug interactions. Notable interactions include simvastatin, pravastatin, fenofibrate. Always inform your doctor about all medications you are taking.

What drug class is bempedoic acid/ezetimibe?

bempedoic acid/ezetimibe belongs to the ACL Inhibitor / Cholesterol Absorption Inhibitor drug class. It requires a prescription (Rx). Nexlizet is used to lower LDL-C (bad cholesterol) in adults who have high cholesterol.

Is bempedoic acid/ezetimibe safe during pregnancy?

This medicine may harm your unborn baby. Do not take Nexlizet if you are pregnant or planning to become pregnant. Always consult your healthcare provider before using any medication during pregnancy or breastfeeding.

Related Medications in ACL Inhibitor / Cholesterol Absorption Inhibitor

Other drugs grouped near bempedoic acid/ezetimibe - same-class peers and common alternatives.

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