Pegloticase and Methotrexate Interaction
Drug interaction information between Pegloticase and Methotrexate.
Pegloticase and Methotrexate have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Pegloticase and Methotrexate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking methotrexate along with pegloticase can cause the levels of pegloticase to stay higher in your blood than usual.
FDA Label Information
7 DRUG INTERACTIONS 7.1 Methotrexate KRYSTEXXA 8 mg every 2 weeks has been studied in patients with chronic gout refractory to conventional therapy taking concomitant oral methotrexate 15 mg weekly [see Clinical Studies (14) ] . Co-administration of methotrexate with KRYSTEXXA may increase pegloticase concentration compared to KRYSTEXXA alone [see Clinical Pharmacology (12.3) ] .
Methotrexate Also Interacts With
- Celecoxib moderate
- Diflunisal moderate
- Indomethacin moderate
- Mefenamic Acid moderate
- Meloxicam moderate
Frequently Asked Questions
What SPL severity band is on file for Pegloticase + Methotrexate?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Methotrexate has 38 labeled pairs on file vs Pegloticase's 2. In the minor band specifically: Pegloticase has 1; Methotrexate has 26 (also Aspirin, Folic Acid, Probenecid, Phenytoin).
What mechanism field is on file for Pegloticase and Methotrexate?
Taking methotrexate along with pegloticase can cause the levels of pegloticase to stay higher in your blood than usual.
Pegloticase carries more major-labeled pairs than Methotrexate
SPL source-record counts only. This page's band is minor · classes on file: Pegloticase (Recombinant Uricase); Methotrexate (Disease-Modifying Antirheumatic Drug (DMARD)).
Pegloticase has 1 major-labeled pair vs Methotrexate's 0. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 1 minor · 2 total
Pegloticase has no other minor-band peer in this dataset besides Methotrexate.
0 major · 12 moderate · 26 minor · 38 total
- Other minor peers for Methotrexate
- Aspirin
- Folic Acid
- Probenecid
- Phenytoin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.