Aprepitant · more major-labeled pairs than Dexamethasone
SPL labels Dexamethasone + Aprepitant as minor; Dexamethasone 18 / Aprepitant 12 in that band.
Mechanism on file: Aprepitant slows down how your body breaks down dexamethasone, which causes the steroid levels to stay in your system longer.
FDA SPL severity: Minor
Dexamethasone + Aprepitant · SPL mechanism field
Aprepitant slows down how your body breaks down dexamethasone, which causes the steroid levels to stay in your system longer.
Minor band excerpt · Dexamethasone with Aprepitant
Depending on the clinical situation (e.g., elderly patients) and degree of monitoring available, reduce the dose of intravenous midazolam Single 40 mg dose of aprepitant No dosage adjustment of the benzodiazepine needed Dexamethasone Clinical Impact Increased dexamethasone exposure [see Clinical Pharmacology ( 12.3 )]. Intervention 3-day aprepitant regimen Reduce the dose of oral dexamethasone by approximately 50% [see Dosage and Administration ( 2.1 )]. Single 40 mg dose of aprepitant No dosage adjustment of oral dexamethasone needed Methylprednisolone Clinical Impact Increased...
Dexamethasone · 18 minor + 21 total pairs
- Albendazole minor
- Amphotericin B minor
- Carbamazepine minor
- Caspofungin minor
Aprepitant · 1 major-labeled pairs (vs Dexamethasone's 0)
- Carbamazepine minor
- Estradiol minor
- Ethinyl Estradiol/Etonogestrel minor
- Ethinyl Estradiol/Norgestimate minor
FDA Drug Labels (SPL) via openFDA. Registry display only. Not medical advice.
Read our methodology - how this data is sourced, computed, and verified.