Clindamycin and Clindamycin Topical Interaction
Drug interaction information between Clindamycin and Clindamycin Topical.
Clindamycin and Clindamycin Topical have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Clindamycin and Clindamycin Topical. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clindamycin can increase the effects of drugs used to relax muscles during surgery. This could make the muscle-relaxing effect stronger or last longer than intended.
FDA Label Information
Drug Interactions Clindamycin has been shown to have neuromuscular blocking properties that may enhance the action of other neuromuscular blocking agents.
Frequently Asked Questions
What SPL severity band is on file for Clindamycin + Clindamycin Topical?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clindamycin has 2 labeled pairs on file vs Clindamycin Topical's 1. In the minor band specifically: Clindamycin has 2 (also Colestipol); Clindamycin Topical has 1.
What mechanism field is on file for Clindamycin and Clindamycin Topical?
Clindamycin can increase the effects of drugs used to relax muscles during surgery. This could make the muscle-relaxing effect stronger or last longer than intended.
Clindamycin's labeled portfolio outnumbers Clindamycin Topical
SPL source-record counts only. This page's band is minor · classes on file: Clindamycin (Lincosamide Antibiotic); Clindamycin Topical (Topical Antibiotic).
0 major · 0 moderate · 1 minor · 1 total
Clindamycin Topical has no other minor-band peer in this dataset besides Clindamycin.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.