MID-VOLUME · FEMALE-LED

progesterone Side Effects

progesterone (also sold as Prometrium) sits MID-VOLUME #229 of 524 by FAERS report count. Lead signal: FEMALE-LED - 97% of sex-coded reports are female (18,521 F / 608 M). Demographics and serious-outcome tables follow.

Data updated 2026-05-15

21,004
FAERS reports

FDA Adverse Event Reporting System extract for progesterone. Stamp set WATCHLIST · DEATH-MARKED · HOSP-MID. How figures are compiled.

progesterone reporting skew - 97% of sex-coded reports are female (18,521 F / 608 M). Volume band MID-VOLUME #229 of 524 by FAERS report count; caseload WATCHLIST.

Mid-book FAERS page for progesterone (Prometrium) (21,004 reports). Signature FEMALE-LED. Dominant age band on file: 45-64. Educational reference only.

Counts from the openFDA FAERS extract (2004–2025). Stamps WATCHLIST · DEATH-MARKED · HOSP-MID · FEMALE-LED.

HEADACHE leads 1,946 of 21,004 reports

HEADACHE
1,946
FATIGUE
1,673
PAIN
1,370
NAUSEA
1,362
RASH
903
DIZZINESS
886
EXPOSURE DURING PREGNANCY
879
HYPERSENSITIVITY
802
HYPERHIDROSIS
783
DIARRHOEA
779
MATERNAL EXPOSURE DURING PREGNANCY
763
BACK PAIN
761
INSOMNIA
742
CONSTIPATION
714
ARTHRALGIA
699
ANXIETY
686
PYREXIA
675

FEMALE-LED reporters · age peak 45-64

Female-led reporters (97% of sex-coded rows)

Female 18,521 (97%)
Male 608 (3%)
Unknown 46

Age peak 45-64 (6,819 reports)

0-17 434 (4%)
18-44 3,506 (28%)
45-64 6,819 (55%)
65-74 1,251 (10%)
75+ 320 (3%)

FAERS filings rising toward 2025

2004 2025

Reactions in Death Reports

Death appears on 476 reports (2.3% - MARKED). Reactions below co-occur in those rows only.

Reaction Reports
FOETAL DEATH 129
THROMBOCYTOPENIA 129
PYREXIA 126
HEADACHE 125
PAIN 125
PSORIASIS 121
FATIGUE 120
HYPERTENSION 120
PRESCRIBED OVERDOSE 118
RHEUMATOID ARTHRITIS 118
TEMPERATURE REGULATION DISORDER 118
UPPER RESPIRATORY TRACT INFECTION 118
FLUID RETENTION 117
HEPATIC ENZYME INCREASED 116
JOINT SWELLING 116
CONTRAINDICATED PRODUCT ADMINISTERED 115

Reactions in Hospitalization Reports

Hospitalization mid-share (3,394, 16.2%). Co-reported reactions:

Reaction Reports
OVARIAN HYPERSTIMULATION SYNDROME 266
DYSPNOEA 250
FATIGUE 241
HEADACHE 236
NAUSEA 234
PAIN 205
VOMITING 186
DIARRHOEA 173
DIZZINESS 166
PYREXIA 162
MATERNAL EXPOSURE DURING PREGNANCY 156
FALL 146
ABDOMINAL PAIN 136
ANXIETY 135
ARTHRALGIA 132
ASTHENIA 128
PNEUMONIA 120
FOETAL EXPOSURE DURING PREGNANCY 117
How to read progesterone FAERS figures (WATCHLIST · DEATH-MARKED · HOSP-MID)

FAERS holds 21,004 voluntary reports linked to progesterone (Prometrium), 2004-2025. Death is listed on 476 (2.3%). Hospitalization appears on 3,394 (16.2%). Top co-reported indication: Product Used For Unknown Indication.

Mid-volume extract - treat DEATH-MARKED · HOSP-MID as signal-detection rates next to 97% of sex-coded reports are female (18,521 F / 608 M).

Read with progesterone

Peers ranked by ABS(total_reports), then an ABS(death_share) pole; guide hop follows DEATH-MARKED · HOSP-MID stamps.