pitavastatin vs rosuvastatin
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of pitavastatin and rosuvastatin. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Livalo
Crestor
Pitavastatin (Livalo) is a drug that helps lower bad cholesterol (LDL-C) in your blood. It is used along with a healthy diet.
Rosuvastatin is a drug that lowers cholesterol. It helps to reduce the risk of heart problems and stroke.
Pitavastatin is used to lower LDL-C (bad cholesterol) in adults. It is for adults who have high cholesterol or who have a genetic condition called heterozygous familial hypercholesterolemia (HeFH). This medicine works best when you also follow a low-cholesterol diet.
Rosuvastatin is used to lower bad cholesterol (LDL) in adults and children. It can also slow down the hardening of arteries in adults. This medicine also treats high triglycerides and certain inherited cholesterol disorders.
Pitavastatin belongs to a class of drugs called statins. It works by blocking a substance your body needs to make cholesterol. This helps to lower the amount of cholesterol in your blood.
Rosuvastatin belongs to a class of drugs called statins. It works by blocking a substance your body needs to make cholesterol. This helps to lower your cholesterol levels.
- • Muscle pain
- • Constipation
- • Back pain
- • Diarrhea
- • Pain in your arms or legs
- • Headache
- • Nausea
- • Muscle pain
- • Weakness
- • Constipation
- Myalgia 408
- Diarrhoea 335
- Dizziness 285
- Dyspnoea 281
- Decreased Appetite 280
- Fatigue 11,700
- Nausea 10,039
- Dyspnoea 9,208
- Diarrhoea 9,198
- Myalgia 8,784
Pitavastatin can cause muscle problems, including myopathy and rhabdomyolysis. Tell your doctor right away if you have unexplained muscle pain, tenderness, or weakness, especially if you also have a fever or feel sick. Pitavastatin can also cause liver problems. Your doctor may do blood tests to check your liver before and during treatment.
Rosuvastatin can cause muscle problems, including muscle pain, tenderness, or weakness. Tell your doctor right away if you have these symptoms, especially if you also have a fever or feel sick. Rosuvastatin can also cause liver problems. Your doctor may do blood tests to check your liver before and during treatment.
Do not take pitavastatin if you are pregnant. It can harm your unborn baby. Breastfeeding is also not recommended while taking this medicine.
Do not take rosuvastatin if you are pregnant. It can harm your unborn baby. Talk to your doctor about other ways to control your cholesterol during pregnancy. Breastfeeding is not recommended while taking rosuvastatin.
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How to Read This pitavastatin vs rosuvastatin Comparison
pitavastatin is classified in the HMG-CoA Reductase Inhibitor (Statin) drug class, while rosuvastatin sits within the HMG-CoA Reductase Inhibitor (Statin) class. Because both drugs share the same classification, they are often considered interchangeable in theory, but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, pitavastatin has 1,589 submissions while rosuvastatin has 48,929. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for pitavastatin or rosuvastatin.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.