morphine vs trazodone
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Side-by-side comparison of morphine and trazodone. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Examples: Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that effect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue).
Morphine is a strong pain medicine. It is used to treat severe pain that needs an opioid medicine when other treatments don't work well enough.
Trazodone is a medicine used to treat depression. It helps to improve your mood and can help you sleep better.
Morphine is used to manage severe pain in adults and children who weigh at least 110 pounds. It is for pain that requires an opioid medicine. It is used when other pain treatments are not strong enough or cannot be tolerated.
Trazodone is used to treat major depressive disorder (MDD) in adults. This medicine can help improve your mood and reduce symptoms of depression. Talk to your doctor if you have any questions about why you are taking this medication.
Morphine works by attaching to receptors in the brain and spinal cord. These receptors are involved in sending pain signals. By binding to these receptors, morphine blocks pain signals and reduces pain.
Trazodone is a selective serotonin reuptake inhibitor (SSRI). It works by increasing the amount of serotonin in your brain. Serotonin is a chemical that helps regulate mood.
- • Constipation
- • Nausea
- • Feeling sleepy
- • Lightheadedness
- • Dizziness
- • Swelling
- • Blurred vision
- • Fainting
- • Drowsiness
- • Tiredness
- Pain 5,858
- Nausea 5,536
- Vomiting 4,337
- Death 4,306
- Fatigue 4,130
- Fatigue 1,129
- Nausea 1,097
- Headache 909
- Pain 808
- Diarrhoea 793
Morphine can cause addiction, abuse, and misuse, which can lead to overdose and death. It can also cause life-threatening breathing problems, especially when you start taking it or after a dose increase. Accidental ingestion, especially by children, can cause a fatal overdose. Taking morphine with benzodiazepines or other CNS depressants (including alcohol) can cause severe sedation, breathing problems, coma, and death. If you use morphine for a long time during pregnancy, your baby could have withdrawal symptoms after birth.
Antidepressants may increase the risk of suicidal thoughts and behaviors in young adults. Your doctor will monitor you closely for worsening depression or suicidal thoughts. Trazodone is not approved for use in children.
Morphine may harm your unborn baby. Using morphine for a long time during pregnancy can cause withdrawal symptoms in the newborn. Tell your doctor if you are pregnant or plan to become pregnant.
Tell your doctor if you are pregnant or plan to become pregnant. It is important to consider the risk of untreated depression during pregnancy. There is a pregnancy registry to monitor outcomes in women exposed to antidepressants during pregnancy. You can register by calling 1-844-405-6185.
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How to Read This morphine vs trazodone Comparison
morphine is classified in the Opioid Analgesic drug class, while trazodone sits within the Serotonin Antagonist and Reuptake Inhibitor (SARI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, morphine has 24,167 submissions while trazodone has 4,736. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to both drugs can increase a brain chemical called serotonin, which may lead to a rare but serious reaction.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for morphine or trazodone.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.