metformin vs trimethoprim
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Side-by-side comparison of metformin and trimethoprim. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Sulfamethoxazole and trimethoprim potentiates the effect of oral hypoglycemics that are metabolized by CYP2C8 (e.g., pioglitazone, repaglinide, and rosiglitazone) or CYP2C9 (e.g., glipizide and glyburide) or eliminated renally via OCT2 (e.g., metformin). Cases of interactions with other OCT2 substrates, memantine and metformin, have also been reported.
Glucophage, Fortamet, Glumetza
Primsol
No summary available.
This medicine contains sulfamethoxazole and trimethoprim. It is an antibiotic that fights bacteria in your body.
Information not available.
This medicine can treat urinary tract infections, ear infections in children, and bronchitis in adults. It also treats shigellosis, a type of diarrhea. It can also treat or prevent Pneumocystis jiroveci pneumonia, and treat traveler's diarrhea.
Information not available.
This medicine works by stopping bacteria from making folic acid. Bacteria need folic acid to grow and multiply. By blocking folic acid production, the medicine kills the bacteria.
- • Diarrhea
- • Upper respiratory tract infection (like a cold)
- • Headache
- • Nausea
- • Vomiting
- • Loss of appetite
- • Skin rash
- • Hives
- Nausea 21,946
- Diarrhoea 21,884
- Blood Glucose Increased 18,328
- Fatigue 17,252
- Acute Kidney Injury 16,440
- Nausea 945
- Diarrhoea 848
- Headache 835
- Malaise 816
- Pyrexia 721
No specific warnings noted.
Rarely, sulfonamide drugs like this one have caused severe reactions. These include Stevens-Johnson syndrome, toxic epidermal necrolysis, liver damage, and blood problems. Tell your doctor right away if you have a fever, rash, blisters, mouth sores, or signs of infection.
No pregnancy information available.
Tell your doctor if you are pregnant or plan to become pregnant. This medicine may not be safe for your baby. Talk to your doctor about the risks and benefits of taking this medicine while breastfeeding.
How to Read This metformin vs trimethoprim Comparison
metformin is classified in the Biguanide drug class, while trimethoprim sits within the Dihydrofolate Reductase Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, metformin has 95,850 submissions while trimethoprim has 4,165. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to trimethoprim can stop your kidneys from clearing metformin out of your body as fast as they should.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for metformin or trimethoprim.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.