letrozole vs letrozole (fertility)
Side-by-side comparison of letrozole and letrozole (fertility). Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
7 DRUG INTERACTIONS Tamoxifen Coadministration of Femara and tamoxifen 20 mg daily resulted in a reduction of letrozole plasma levels of 38% on average (Study P015). Clinical experience in the second-line breast cancer trials (AR/BC2 and AR/BC3) indicates that the therapeutic effect of Femara therapy is not impaired if Femara is administered immediately after tamoxifen. Cimetidine A pharmacokinetic interaction study with cimetidine (Study P004) showed no clinically significant effect on letrozole pharmacokinetics.
Recommendation: No special changes or dosage adjustments are needed when taking these two medications together.
Femara
Femara
Letrozole is a medicine that lowers estrogen levels in women after menopause. It is used to treat breast cancer that is affected by hormones.
Letrozole (Femara) is a medicine that lowers estrogen levels in women after menopause. It is used to treat certain types of breast cancer.
Letrozole is used to treat breast cancer in women who have gone through menopause. It can be used as an initial treatment, after other treatments like tamoxifen, or when the cancer has spread. It works best for cancers that are hormone receptor positive or when the hormone receptor status is unknown.
Letrozole is used to treat breast cancer in women who have gone through menopause. It can be used as an initial treatment, after other treatments like tamoxifen, or if the cancer has spread. It works best for cancers that are hormone receptor positive or when the hormone receptor status is unknown.
Letrozole blocks a protein called aromatase in the body. Aromatase makes estrogen. By blocking aromatase, letrozole lowers the amount of estrogen, which can slow or stop the growth of breast cancer cells that need estrogen to grow.
Letrozole belongs to a class of drugs called aromatase inhibitors. It works by blocking an enzyme called aromatase, which the body uses to make estrogen. By lowering estrogen levels, letrozole can help slow or stop the growth of breast cancer cells that need estrogen to grow.
- • Hot flashes
- • Joint pain
- • Flushing
- • Weakness
- • Swelling
- • Hot flashes
- • Joint pain
- • Flushing
- • Weakness
- • Swelling
- Tiredness 7,158
- Feeling sick to your stomach 5,259
- Low white blood cell count 4,896
- Loose stools 4,460
- Cancer getting worse 4,253
No adverse event reports.
Letrozole can cause bone thinning, which may lead to fractures. Your doctor may monitor your bone density. Letrozole can also harm an unborn baby, so you must not take it if you are pregnant. Use effective birth control if you could become pregnant.
Letrozole can cause thinning of your bones, so your doctor may monitor your bone density. It can also increase your cholesterol levels, so your doctor may check your cholesterol. Letrozole can cause harm to an unborn baby. If you are able to become pregnant, you should have a pregnancy test before starting letrozole and use effective birth control while taking it.
Do not take letrozole if you are pregnant because it can harm your unborn baby. If there is any chance you could become pregnant, use birth control while taking letrozole. Do not breastfeed while taking letrozole.
Do not take letrozole if you are pregnant. It can harm your unborn baby. Do not breastfeed while taking letrozole, as it is not known if the drug passes into breast milk.
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How to Read This letrozole vs letrozole (fertility) Comparison
letrozole is classified in the Aromatase Inhibitor drug class, while letrozole (fertility) sits within the Aromatase Inhibitor (Off-Label Fertility) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, letrozole has 26,026 submissions while letrozole (fertility) has 0. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to cimetidine does not have a meaningful effect on how letrozole is processed or used by the body.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between letrozole and letrozole (fertility) - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.