ketoconazole vs midazolam
Side-by-side comparison of ketoconazole and midazolam. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Other Drug Interactions Caution is advised when midazolam is administered concomitantly with drugs that are known to inhibit the P450-3A4 enzyme system such as cimetidine (not ranitidine), erythromycin, diltiazem, verapamil, ketoconazole and itraconazole.
Recommendation: Use this combination with caution as it may cause increased sleepiness. Your doctor may need to lower your dose of midazolam.
Nizoral
Versed
Ketoconazole shampoo is an antifungal medicine. It treats a fungal infection on your skin.
Midazolam is a medicine that makes you feel calm, relaxed, and sleepy. It can also cause you to forget things that happen while you are taking it.
This shampoo treats tinea versicolor, a fungal infection. This infection can cause patches on your skin that are lighter or darker than the surrounding skin. These patches may appear on your trunk, neck, arms, and upper thighs.
Midazolam is used to sedate you before a surgery or procedure to help you relax and feel less anxious. It can also be used to help you feel calm during procedures like bronchoscopies or endoscopies. Midazolam can also be used to start general anesthesia before you get other medicines.
Ketoconazole is an antifungal medicine. It works by stopping the growth of the fungus. This helps to clear up the infection.
Midazolam belongs to a class of drugs called benzodiazepines. It works by slowing down activity in your brain and nervous system. This helps to reduce anxiety, promote relaxation, and cause sleepiness.
No common side effects listed.
- • Decreased breathing rate
- • Tenderness at the injection site
- • Pain during injection
- Feeling tired 929
- Itching 902
- Feeling sick to your stomach 834
- Skin breakout 802
- Loose stool 760
- Convulsions 1,373
- Low blood pressure 1,296
- Medicine affecting another medicine 1,088
- Poisoning from different substances 846
- Sudden kidney damage 845
You should not use this shampoo if you are allergic to ketoconazole or any of the other ingredients.
Midazolam can cause serious breathing problems, including slowed or stopped breathing. This is more likely to happen if you are also taking opioid pain medicines. You must be closely monitored by trained medical staff while receiving midazolam. Make sure the facility has the equipment and medicines needed to treat breathing problems immediately.
It is not known if ketoconazole shampoo can harm an unborn baby. Talk to your doctor if you are pregnant or breastfeeding before using this medicine.
Tell your doctor if you are pregnant or plan to become pregnant. Midazolam may harm an unborn baby. It is not known if midazolam passes into breast milk. Talk to your doctor about the risks and benefits of using this medicine while breastfeeding.
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How to Read This ketoconazole vs midazolam Comparison
ketoconazole is classified in the Azole Antifungal drug class, while midazolam sits within the Benzodiazepine class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, ketoconazole has 4,227 submissions while midazolam has 5,448. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to ketoconazole blocks the specific liver enzyme that your body uses to break down midazolam. this can cause the midazolam to build up in your system and make its effects much stronger.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between ketoconazole and midazolam - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.