hydromorphone vs trazodone
Side-by-side comparison of hydromorphone and trazodone. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Examples: Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue).
Recommendation: Tell your doctor immediately if you feel confused, agitated, or have a very fast heartbeat while taking these together.
Dilaudid
Desyrel
Hydromorphone (Dilaudid) is a strong pain medicine. It is used to treat severe pain when other pain medicines do not work well enough.
Trazodone is a medicine used to treat depression. It helps to improve your mood and can help you sleep better.
This medicine treats severe pain that requires an opioid pain medicine. It is for use when other treatments are not adequate. Do not use it for long periods unless your pain stays severe and other options are still not adequate. This medicine carries risks of addiction, abuse, and misuse.
Trazodone is used to treat major depressive disorder (MDD) in adults. This medicine can help improve your mood and reduce symptoms of depression. Talk to your doctor if you have any questions about why you are taking this medication.
Hydromorphone works by binding to receptors in the brain and spinal cord. This blocks pain signals from reaching the brain. This results in a decreased feeling of pain.
Trazodone is a selective serotonin reuptake inhibitor (SSRI). It works by increasing the amount of serotonin in your brain. Serotonin is a chemical that helps regulate mood.
- • Lightheadedness
- • Dizziness
- • Sleepiness
- • Nausea
- • Vomiting
- • Swelling
- • Blurred vision
- • Fainting
- • Drowsiness
- • Tiredness
- Addiction to the drug 35,077
- Taking too much of the drug 22,994
- Pain 22,132
- Emotional upset 17,685
- Death 14,869
- Tiredness 1,129
- Feeling sick to your stomach 1,097
- Head pain 906
- General discomfort 806
- Loose stools 792
This medicine has a boxed warning. It can cause serious and life-threatening risks. Taking too much can cause overdose and death. It can cause addiction, abuse, and misuse. It can also cause very slow or stopped breathing. Accidental intake, especially by a child, can cause a fatal overdose. Taking with alcohol or other depressants can cause coma and death. If you are pregnant, long-term use can cause withdrawal symptoms in the newborn.
Antidepressants may increase the risk of suicidal thoughts and behaviors in young adults. Your doctor will monitor you closely for worsening depression or suicidal thoughts. Trazodone is not approved for use in children.
Using this medicine for a long time during pregnancy can cause withdrawal symptoms in the baby after birth. Talk to your doctor if you are pregnant or plan to become pregnant. This medicine may not be recommended during labor.
Tell your doctor if you are pregnant or plan to become pregnant. It is important to consider the risk of untreated depression during pregnancy. There is a pregnancy registry to monitor outcomes in women exposed to antidepressants during pregnancy. You can register by calling 1-844-405-6185.
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How to Read This hydromorphone vs trazodone Comparison
hydromorphone is classified in the Opioid Analgesic drug class, while trazodone sits within the Serotonin Antagonist and Reuptake Inhibitor (SARI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, hydromorphone has 112,757 submissions while trazodone has 4,730. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to both of these medications can increase the levels of a brain chemical called serotonin, which can lead to a serious reaction.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between hydromorphone and trazodone - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.