fluoxetine vs propafenone
Side-by-side comparison of fluoxetine and propafenone. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Coadministration of fluoxetine with other drugs that are metabolized by CYP2D6, including certain antidepressants (e.g., TCAs), antipsychotics (e.g., phenothiazines and most atypicals), and antiarrhythmics (e.g., propafenone, flecainide, and others) should be approached with caution. Drugs with a narrow therapeutic index represent the greatest concern (e.g., flecainide, propafenone, vinblastine, and TCAs).
Recommendation: This combination should be used with caution. Your doctor should monitor you closely for side effects or adjust your medication levels.
Prozac, Sarafem
Rythmol
Fluoxetine is a medicine that can help treat depression and other mental health conditions. It belongs to a class of drugs called selective serotonin reuptake inhibitors (SSRIs).
Propafenone (Rythmol) is a medicine that helps control irregular heartbeats. It works by slowing down electrical signals in the heart.
Fluoxetine can treat major depressive disorder in adults and children. It also treats obsessive-compulsive disorder (OCD) in adults and children. Fluoxetine can help with bulimia nervosa (an eating disorder) and panic disorder. Sometimes, it is used with another medicine called olanzapine to treat depression related to bipolar disorder.
This medicine is used to help keep your heart rhythm normal if you have atrial fibrillation or supraventricular tachycardia. These are types of fast or irregular heartbeats that can cause problems. It can also treat life-threatening ventricular arrhythmias. Propafenone is for people without structural heart disease.
Fluoxetine works by increasing the amount of serotonin in your brain. Serotonin is a chemical that helps regulate mood. By increasing serotonin, fluoxetine can help improve mood and reduce symptoms of depression, OCD, and other conditions.
Propafenone works by affecting the electrical activity in your heart. It slows down the signals that cause irregular heartbeats. This helps your heart beat more regularly.
- • Abnormal dreams
- • Problems ejaculating
- • Loss of appetite
- • Feeling anxious
- • Feeling weak
- • Unusual taste
- • Nausea
- • Vomiting
- • Dizziness
- • Constipation
- The medicine is interacting with another medicine 3,336
- Harmful effect from different substances 3,316
- Feeling sick to your stomach 3,233
- Feeling tired 3,155
- Death by suicide 2,904
- Irregular heartbeat in the upper chambers of the heart 347
- Medicine interacting with another medicine 320
- Feeling lightheaded or unsteady 261
- Harmful effect from different substances 231
- Shortness of breath 226
Antidepressants may increase the risk of suicidal thoughts and behaviors in children, teenagers, and young adults. Watch closely for worsening depression or suicidal thoughts. Tell your doctor right away if you notice any changes in mood or behavior. Fluoxetine is not approved for use in children younger than 7 years old.
This medicine may increase the risk of death in people with heart problems. Do not take this medicine if you have structural heart disease and non-life-threatening ventricular arrhythmias. Talk to your doctor about the risks and benefits of taking this medicine.
Talk to your doctor if you are pregnant or plan to become pregnant. Fluoxetine should only be used during pregnancy if the benefit outweighs the risk to the baby. Breastfeeding is not recommended while taking fluoxetine.
Tell your doctor if you are pregnant or plan to become pregnant. This medicine can cross the placenta, and may affect the baby. Your doctor will monitor you and your baby for any problems.
Also Compare, Nearby Drugs
Compare fluoxetine with
Compare propafenone with
How to Read This fluoxetine vs propafenone Comparison
fluoxetine is classified in the Selective Serotonin Reuptake Inhibitor (SSRI) drug class, while propafenone sits within the Class IC Antiarrhythmic class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, fluoxetine has 15,944 submissions while propafenone has 1,385. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to fluoxetine slows down how fast your body processes propafenone. this can lead to higher amounts of the heart medicine in your system than intended.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between fluoxetine and propafenone - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.