etodolac vs methotrexate
Side-by-side comparison of etodolac and methotrexate. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Cyclosporine, Digoxin, Methotrexate Etodolac, like other NSAIDs, through effects on renal prostaglandins, may cause changes in the elimination of these drugs leading to elevated serum levels of cyclosporine, digoxin, methotrexate, and increased toxicity. NSAIDs, such as etodolac, should not be administered prior to or concomitantly with high doses of methotrexate. NSAIDs have been reported to competitively inhibit methotrexate accumulation in rabbit kidney slices.
Recommendation: Do not take these two medicines together, especially if you are taking a high dose of methotrexate. Your doctor may need to check your blood levels or change your treatment.
Lodine
Trexall, Otrexup
Etodolac is a pain reliever and anti-inflammatory medicine. It helps reduce pain, swelling, and stiffness caused by arthritis and other conditions.
Methotrexate is a drug that can treat certain cancers, rheumatoid arthritis, psoriasis, and other conditions. It works by slowing the growth of cells in the body.
Etodolac treats the symptoms of osteoarthritis and rheumatoid arthritis. It can help with pain and swelling in your joints. Etodolac is also used for short-term relief of acute pain.
Methotrexate can treat acute lymphoblastic leukemia, a type of cancer, in adults and children. It also treats mycosis fungoides, a skin lymphoma, in adults. Additionally, it treats relapsed or refractory non-Hodgkin lymphoma in adults. For non-cancer conditions, it treats rheumatoid arthritis in adults, polyarticular juvenile idiopathic arthritis (pJIA) in children, and severe psoriasis in adults.
Etodolac is an NSAID, which stands for Nonsteroidal Anti-Inflammatory Drug. It works by reducing substances in the body that cause pain and inflammation. It can help to reduce fever as well.
Methotrexate blocks an enzyme called dihydrofolate reductase. This enzyme is needed for cells to grow and multiply. By blocking this enzyme, methotrexate slows down the growth of cells, especially cancer cells and cells that cause inflammation in arthritis and psoriasis.
- • Upset stomach
- • Constipation
- • Diarrhea
- • Gas
- • Heartburn
- • Mouth sores
- • Nausea
- • Abdominal pain
- • Changes in liver tests
- Pain 350
- Feeling sick to your stomach 290
- Joint pain 284
- Tiredness 273
- Headache 239
- Rheumatoid arthritis 38,053
- Joint pain 36,283
- Pain 35,412
- Tiredness 29,061
- Feeling sick to your stomach 24,011
NSAIDs like etodolac can increase your risk of heart attack or stroke, which can be fatal. This risk may happen early in treatment and increases with longer use. You should not take etodolac if you are having heart bypass surgery. NSAIDs also increase the risk of serious stomach problems like bleeding and ulcers, which can be fatal. Older adults are at higher risk for these stomach problems.
Methotrexate can cause serious harm to an unborn baby, including death. If you are pregnant, you should not take this medicine for non-cancer conditions. If you are taking it for cancer, talk to your doctor about the risks. This medicine can also cause severe allergic reactions and other serious side effects that can be life-threatening. Contact your doctor immediately if you experience any signs of infection, lung problems, or kidney problems.
Talk to your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. Etodolac may harm your unborn baby. It is not known if etodolac passes into breast milk.
Methotrexate can cause birth defects or fetal death if taken during pregnancy for non-cancer conditions. If you are pregnant or plan to become pregnant, talk to your doctor. Do not breastfeed while taking methotrexate, as it can pass into breast milk and harm your baby.
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How to Read This etodolac vs methotrexate Comparison
etodolac is classified in the Nonsteroidal Anti-Inflammatory Drug (NSAID) drug class, while methotrexate sits within the Disease-Modifying Antirheumatic Drug (DMARD) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, etodolac has 1,436 submissions while methotrexate has 162,820. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to etodolac can slow down how fast your kidneys remove methotrexate from your body, which causes the drug to build up to unsafe levels. this buildup can make the side effects of methotrexate more dangerous.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between etodolac and methotrexate - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.