erythromycin vs rivaroxaban
Side-by-side comparison of erythromycin and rivaroxaban. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Interaction with Combined P-gp and Moderate CYP3A Inhibitors in Patients with Renal Impairment XARELTO should not be used in patients with CrCl 15 to <80 mL/min who are receiving concomitant combined P-gp and moderate CYP3A inhibitors (e.g., erythromycin) unless the potential benefit justifies the potential risk [see Warnings and Precautions (5.4) and Clinical Pharmacology (12.3) ] .
Recommendation: Avoid this combination if you have kidney problems unless your doctor decides the benefits are worth the risk.
E-Mycin, Ery-Tab
Xarelto
Erythromycin Topical Solution is a medicine that you put on your skin to treat acne. It contains an antibiotic to help clear up your skin.
Rivaroxaban (Xarelto) is a drug that helps to prevent blood clots from forming. It is used to lower the risk of stroke and treat or prevent dangerous clots in your veins and lungs.
Erythromycin Topical Solution treats acne vulgaris. This medicine helps to reduce acne on your face, neck, shoulders, chest, and back. It works by fighting the bacteria that cause acne.
This medicine can help prevent strokes in people with an irregular heartbeat called atrial fibrillation. It also treats blood clots in the legs (deep vein thrombosis or DVT) and lungs (pulmonary embolism or PE). Rivaroxaban can also lower the risk of these clots coming back. It is also used to prevent blood clots after hip or knee replacement surgery and in acutely ill patients.
Erythromycin is a macrolide antibiotic. It works by stopping the growth of bacteria. This helps to reduce inflammation and clear up acne.
Rivaroxaban is a factor Xa inhibitor. It blocks a substance in your blood called factor Xa. By blocking factor Xa, the medicine helps to prevent blood clots from forming.
- • Peeling
- • Dryness
- • Itching
- • Redness
- • Oily skin
- • Bleeding
- • Cough
- • Vomiting
- • Gastroenteritis (inflammation of the stomach and intestines)
- Drug Hypersensitivity 4,088
- Nausea 1,271
- Vomiting 1,121
- Diarrhoea 1,069
- Dyspnoea 1,023
- Bleeding in the stomach or intestines 21,559
- Bleeding 7,713
- Shortness of breath 7,149
- Nosebleed 6,698
- Tiredness 6,546
You should not use this medicine if you are allergic to any of its ingredients.
This medicine has two important warnings. First, stopping this medicine too early can increase your risk of blood clots. Do not stop taking it without talking to your doctor first. Second, if you receive spinal anesthesia or have a spinal puncture while taking this medicine, you have a risk of a blood clot forming around your spine, which can cause long-term paralysis.
It is not known if erythromycin topical solution can harm an unborn baby. Talk to your doctor if you are pregnant or breastfeeding.
Talk to your doctor if you are pregnant or plan to become pregnant. This medicine may cause bleeding problems during pregnancy and delivery. It is not known if this medicine passes into breast milk, so talk to your doctor about the risks and benefits of breastfeeding.
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How to Read This erythromycin vs rivaroxaban Comparison
erythromycin is classified in the Macrolide Antibiotic drug class, while rivaroxaban sits within the Direct Oral Anticoagulant (Factor Xa Inhibitor) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, erythromycin has 8,572 submissions while rivaroxaban has 49,665. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to erythromycin slows down how your body breaks down and removes rivaroxaban. this can cause the drug to build up in your system, especially if your kidneys are not working perfectly.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between erythromycin and rivaroxaban - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.