dofetilide vs lamotrigine
Side-by-side comparison of dofetilide and lamotrigine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Coadministration of lamotrigine with OCT2 substrates with a narrow therapeutic index (e.g., dofetilide) is not recommended.
Recommendation: Using these two drugs together is not recommended.
Tikosyn
Lamictal
Dofetilide (Tikosyn) helps keep your heart in a normal rhythm if you have atrial fibrillation or atrial flutter. It can also help convert these abnormal rhythms back to normal.
Lamotrigine is a medicine that can treat seizures and bipolar disorder. It works by reducing irregular electrical activity in the brain.
This medicine is used to maintain a normal heart rhythm if you have atrial fibrillation or atrial flutter for more than a week, and your heart has been returned to a normal rhythm. It can also convert atrial fibrillation and atrial flutter to a normal rhythm. This medicine is for people who have bothersome symptoms from their atrial fibrillation or flutter.
Lamotrigine can treat epilepsy in adults and children 2 years and older. It can help with partial-onset seizures, primary generalized tonic-clonic seizures, and generalized seizures of Lennox-Gastaut syndrome. It can also be used to delay mood episodes in adults with bipolar I disorder.
Dofetilide belongs to a class of drugs called Class III antiarrhythmics. It works by changing the electrical activity in your heart. This helps to stabilize your heart rhythm and prevent irregular heartbeats.
Lamotrigine affects how nerves in the brain send signals to each other. It is thought to work by decreasing the release of certain chemicals. This helps to stabilize electrical activity and prevent seizures or mood swings.
- • Headache
- • Chest pain
- • Dizziness
- • Dizziness
- • Headache
- • Double vision
- • Uncoordinated movements
- • Nausea
- Irregular heartbeat 1,059
- Shortness of breath 603
- Feeling lightheaded 552
- Feeling tired 521
- Death 478
- Skin rash 8,408
- Seizure 6,527
- Feeling sick to your stomach 6,151
- Tiredness 5,914
- Feeling lightheaded 5,771
This drug can cause life-threatening heart rhythm problems. To lower this risk, you must start or restart this medicine in a hospital where your heart can be watched closely for at least 3 days. The hospital staff will check your kidney function and heart rhythm regularly.
Lamotrigine can cause a serious skin rash that may require you to go to the hospital. This rash can be life-threatening. The risk is higher in children. Stop taking lamotrigine and see a doctor right away if you get a rash, fever, or swollen lymph nodes.
Tell your doctor if you are pregnant or plan to become pregnant. It is not known if this medicine will harm your unborn baby. Talk to your doctor about the risks and benefits of taking this medicine while pregnant or breastfeeding.
Tell your doctor if you are pregnant or plan to become pregnant. Lamotrigine may cause harm to an unborn baby. There is a pregnancy registry for women who take lamotrigine during pregnancy. You can enroll by calling 1-888-233-2334.
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How to Read This dofetilide vs lamotrigine Comparison
dofetilide is classified in the Class III Antiarrhythmic drug class, while lamotrigine sits within the Anticonvulsant class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, dofetilide has 3,213 submissions while lamotrigine has 32,771. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to lamotrigine can change how the body handles dofetilide, a drug that can be dangerous if levels are slightly off.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between dofetilide and lamotrigine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.