diclofenac vs meloxicam
PlainMeds reviewed this comparison against our methodology in August 2026. It places FDA and CMS record fields side by side, without recommending either medication.
Side-by-side comparison of diclofenac and meloxicam. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
Voltaren, Cataflam
Mobic
Diclofenac is a gel that helps with arthritis pain in your hands, wrists, elbows, feet, ankles, or knees. It belongs to a class of drugs called NSAIDs.
Meloxicam is a non-steroidal anti-inflammatory drug (NSAID). It helps to reduce pain and swelling.
This medicine temporarily relieves arthritis pain. It is only for pain in your hands, wrists, elbows, feet, ankles, or knees. It may take up to 7 days to start working. If you still have pain after 7 days, stop using it.
Meloxicam treats the symptoms of osteoarthritis and rheumatoid arthritis. It can also treat juvenile rheumatoid arthritis in children who weigh at least 132 pounds (60 kg). This medicine helps to relieve pain, swelling, and stiffness in your joints.
Diclofenac is an NSAID. It reduces pain and swelling by blocking substances in the body that cause inflammation.
Meloxicam works by reducing substances in the body that cause pain and inflammation. It blocks the production of prostaglandins. Prostaglandins contribute to inflammation and pain.
- • Pain
- • Headache
- • Diarrhea
- • Upper respiratory infection
- • Upset stomach
- • Flu-like symptoms
- Pain 12,281
- Fatigue 11,317
- Rheumatoid Arthritis 9,241
- Rash 8,747
- Arthralgia 8,640
- Pain 4,670
- Fatigue 4,578
- Arthralgia 4,222
- Nausea 3,807
- Headache 3,323
No specific warnings noted.
Meloxicam may increase your risk of serious heart problems, including heart attack and stroke, which can be fatal. This risk may occur early in treatment and may increase with longer use. You should not take meloxicam if you are having heart bypass surgery. Meloxicam can also increase your risk of serious stomach and intestinal problems, including bleeding, ulcers, and holes, which can be fatal. These problems can occur without warning. The elderly and those with a history of ulcers are at greater risk.
No pregnancy information available.
Using meloxicam between 20 and 30 weeks of pregnancy may cause kidney problems in the baby, leading to low amniotic fluid. Avoid using meloxicam after 30 weeks of pregnancy because it can cause heart problems in the baby. Talk to your doctor if you are pregnant or plan to become pregnant.
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How to Read This diclofenac vs meloxicam Comparison
diclofenac is classified in the Nonsteroidal Anti-Inflammatory Drug (NSAID) drug class, while meloxicam sits within the Nonsteroidal Anti-Inflammatory Drug (NSAID) class. Because both drugs share the same classification, they are often considered interchangeable in theory, but clinical outcomes rarely track that cleanly. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, diclofenac has 50,226 submissions while meloxicam has 20,600. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for diclofenac or meloxicam.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.