diazepam vs mirtazapine
Side-by-side comparison of diazepam and mirtazapine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Examples diazepam, alprazolam, alcohol Drugs that Prolong QTc Interval Clinical Impact The concomitant use of other drugs which prolong the QTc interval with mirtazapine, increase the risk of QTc prolongation and/or ventricular arrhythmias (e.g., Torsades de Pointes).
Recommendation: Your healthcare provider should check your heart's electrical activity with an EKG. Report any fainting or chest palpitations to your doctor immediately.
Valium
Remeron
Diazepam (Valium) is a medicine that can help with anxiety, muscle spasms, and seizures. It belongs to a class of drugs called benzodiazepines, which work by slowing down the brain.
Mirtazapine is a medicine used to treat depression in adults. It can help improve your mood and energy levels.
Diazepam can help manage anxiety disorders or provide short-term relief from anxiety symptoms. It can also relieve symptoms of alcohol withdrawal, such as shaking or agitation. Additionally, diazepam can help with muscle spasms and may be used with other medicines to treat seizures.
Mirtazapine is used to treat major depressive disorder (MDD) in adults. This condition can cause you to feel sad, lose interest in activities, and have trouble with sleeping or eating. Mirtazapine can help improve these symptoms.
Diazepam works by increasing the effects of a natural chemical in the brain called GABA. GABA helps to calm the brain and nerves. This can reduce anxiety, relax muscles, and prevent seizures.
Mirtazapine works by affecting certain chemicals in the brain called neurotransmitters. It helps to increase the levels of norepinephrine and serotonin. These chemicals can help improve mood and reduce symptoms of depression.
- • Drowsiness
- • Fatigue
- • Muscle weakness
- • Uncoordinated movements
- • Feeling sleepy
- • Increased appetite
- • Weight gain
- • Dizziness
- Harm from certain substances 9,167
- Misuse of medicine 7,019
- Feeling sick to your stomach 6,144
- Feeling tired 5,714
- Discomfort 5,202
- Feeling sick to your stomach 4,838
- Feeling tired 4,714
- Accidentally falling down 4,026
- Loose or watery stools 3,961
- Harm from different substances 3,705
Diazepam can be habit-forming and can cause serious side effects, including breathing problems, coma, and even death, especially when taken with opioid pain medicines or alcohol. You should not stop taking diazepam suddenly, as this can cause withdrawal symptoms. Talk to your doctor about how to slowly stop taking diazepam.
Antidepressants may increase the risk of suicidal thoughts and behaviors in young adults. Your doctor should closely watch you for worsening depression or suicidal thoughts. Mirtazapine is not approved for use in children.
Diazepam may harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if diazepam passes into breast milk, so talk to your doctor before breastfeeding.
Tell your doctor if you are pregnant or plan to become pregnant. Mirtazapine should be used during pregnancy only if clearly needed. Talk to your doctor if you are breastfeeding.
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How to Read This diazepam vs mirtazapine Comparison
diazepam is classified in the Benzodiazepine drug class, while mirtazapine sits within the Noradrenergic and Specific Serotonergic Antidepressant (NaSSA) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, diazepam has 33,246 submissions while mirtazapine has 21,244. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to both medications can interfere with the heart's electrical system when used at the same time. this can lead to serious heart rhythm issues that may be life-threatening.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between diazepam and mirtazapine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.