dextromethorphan vs tranylcypromine
Side-by-side comparison of dextromethorphan and tranylcypromine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Product Clinical Comment on Concomitant Use [See Contraindications (4.1)] ; Predominant Effect/Risk [Hypertensive Reaction (HR) [See Warnings and Precautions (5.3)] ; or Serotonin Syndrome (SS) [See Warnings and Precautions (5.7)] ] Altretamine Use with caution If not otherwise specified in this table, consider avoiding concomitant use (see also information on medication-free intervals , use agent at the lowest appropriate dose, monitor for effects of the interaction, advise the patient to report potential effects, and be prepared to discontinue the agent and treat effects of the...
Recommendation: Avoid taking these drugs together. Ask your doctor or pharmacist for a different cough medicine that does not interact with your antidepressant.
Delsym, Robitussin
Parnate
Dextromethorphan is a medicine that helps to relieve coughs. It can also help with cold and flu symptoms.
Tranylcypromine (Parnate) is a medicine used to treat major depression in adults. It is used when other antidepressants have not worked well enough.
This medicine temporarily relieves symptoms from a cold. It can help with minor aches and pains, headache, and nasal and sinus congestion. It also helps with sore throat, cough due to minor throat and bronchial irritation, and reduces fever.
Tranylcypromine is used to treat major depressive disorder (MDD) in adults. You should only use it if other antidepressants haven't helped. It is not for the first treatment of depression because it can cause serious side effects and has many drug and food interactions.
Dextromethorphan works by decreasing the activity in the part of your brain that causes you to cough. This helps to reduce your urge to cough. It does not treat the underlying cause of the cough.
Tranylcypromine belongs to a class of drugs called MAO inhibitors. It works by increasing the levels of certain chemicals in your brain. These chemicals can help improve your mood.
- • Dizziness
- • Nausea
- • Headache
- • Fatigue
- • Dry mouth
- • Dizziness
- • Trouble sleeping
- • Feeling sleepy
- • Headache
- Misusing the medicine 713
- Poisoning 678
- Taking too much medicine 594
- Feeling lightheaded 435
- Accidentally taking too much medicine 403
- Interaction between medicines 68
- Feeling sad or hopeless 36
- Too much serotonin in the body 27
- Head pain 24
- High blood pressure 24
Do not use in children under 12 years of age.
Tranylcypromine can increase the risk of suicidal thoughts and behaviors in young adults. It can also cause a dangerous increase in blood pressure if you eat foods high in tyramine or take certain medicines. Make sure to follow all food and drug restrictions.
Talk to your doctor before taking this medicine if you are pregnant or breastfeeding. It is not known if this medicine will harm your unborn baby. It is also not known if this medicine passes into breast milk.
There is limited information about the safety of tranylcypromine during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. It is not recommended to breastfeed while taking this medicine because it can harm the baby.
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How to Read This dextromethorphan vs tranylcypromine Comparison
dextromethorphan is classified in the Antitussive drug class, while tranylcypromine sits within the Monoamine Oxidase Inhibitor (MAOI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, dextromethorphan has 2,823 submissions while tranylcypromine has 179. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to these medicines can interact to cause a dangerous spike in blood pressure or a harmful buildup of serotonin. they both affect the way your nervous system manages chemical signals.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between dextromethorphan and tranylcypromine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.