desvenlafaxine vs tranylcypromine
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Side-by-side comparison of desvenlafaxine and tranylcypromine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Other Serotonergic Drugs Clinical Impact Concomitant use of PRISTIQ with other serotonergic drugs increases the risk of serotonin syndrome.
Pristiq
Parnate
Pristiq is a medicine used to treat depression in adults. It belongs to a class of drugs called serotonin-norepinephrine reuptake inhibitors (SNRIs).
Tranylcypromine (Parnate) is a medicine used to treat major depression in adults. It is used when other antidepressants have not worked well enough.
Pristiq is used to treat major depressive disorder (MDD) in adults. MDD can cause you to feel sad, lose interest in activities, and have trouble with daily life. This medicine can help improve your mood and energy levels.
Tranylcypromine is used to treat major depressive disorder (MDD) in adults. You should only use it if other antidepressants haven't helped. It is not for the first treatment of depression because it can cause serious side effects and has many drug and food interactions.
Pristiq works by affecting certain chemicals in the brain. It increases the levels of serotonin and norepinephrine. These chemicals help regulate mood and can improve symptoms of depression.
Tranylcypromine belongs to a class of drugs called MAO inhibitors. It works by increasing the levels of certain chemicals in your brain. These chemicals can help improve your mood.
- • Feeling sick to your stomach
- • Feeling dizzy
- • Trouble sleeping
- • Increased sweating
- • Constipation
- • Dry mouth
- • Dizziness
- • Trouble sleeping
- • Feeling sleepy
- • Headache
- Toxicity To Various Agents 233
- Nausea 206
- Completed Suicide 186
- Anxiety 180
- Overdose 174
- Drug Interaction 68
- Depression 36
- Serotonin Syndrome 27
- Headache 24
- Hypertension 24
Antidepressants may increase the risk of suicidal thoughts and behaviors in children, adolescents, and young adults. If you are started on Pristiq, your doctor will monitor you closely for worsening depression or suicidal thoughts. Families and caregivers should also watch for these changes.
Tranylcypromine can increase the risk of suicidal thoughts and behaviors in young adults. It can also cause a dangerous increase in blood pressure if you eat foods high in tyramine or take certain medicines. Make sure to follow all food and drug restrictions.
Tell your doctor if you are pregnant or plan to become pregnant. Taking Pristiq late in pregnancy may cause problems in the newborn. There is a pregnancy registry to monitor outcomes in women exposed to antidepressants during pregnancy. You can register by calling 1-844-405-6185.
There is limited information about the safety of tranylcypromine during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. It is not recommended to breastfeed while taking this medicine because it can harm the baby.
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How to Read This desvenlafaxine vs tranylcypromine Comparison
desvenlafaxine is classified in the Serotonin-Norepinephrine Reuptake Inhibitor (SNRI) drug class, while tranylcypromine sits within the Monoamine Oxidase Inhibitor (MAOI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, desvenlafaxine has 979 submissions while tranylcypromine has 179. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to both drugs increase the amount of serotonin in the brain. taking them together can cause serotonin levels to become dangerously high, leading to a serious condition called serotonin syndrome.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for desvenlafaxine or tranylcypromine.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.