cyclosporine vs valganciclovir
Side-by-side comparison of cyclosporine and valganciclovir. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Cyclosporine or amphotericin B Unknown Monitor renal function when valganciclovir is coadministered with cyclosporine or amphotericin B because of potential increase in serum creatinine [see Warnings and Precautions (5.2)]. ( 7 ) Cyclosporine or amphotericin B: When coadministered with valganciclovir, the risk of nephrotoxicity may be increased.
Recommendation: Your healthcare provider should monitor your kidney function tests regularly while you are using both drugs.
Neoral, Sandimmune, Restasis
Valcyte
Vevye eye drops contain cyclosporine. They help treat the signs and symptoms of dry eye disease.
Valganciclovir is an antiviral medicine. It helps prevent cytomegalovirus (CMV) disease in children who have received kidney or heart transplants.
Vevye treats the signs and symptoms of dry eye disease. Dry eye can cause discomfort, stinging, and blurred vision. This medicine can help reduce these symptoms.
This medicine prevents CMV disease in children after they get a kidney or heart transplant. CMV is a virus that can cause problems in people with weakened immune systems. Valganciclovir helps to stop the virus from growing and causing illness.
Vevye contains cyclosporine, which is an immunosuppressant. It works by decreasing inflammation in the eyes. This helps your eyes make more tears.
Valganciclovir changes into ganciclovir in your body. Ganciclovir stops CMV from making copies of itself. This helps to prevent or treat CMV infections.
- • Irritation where the drops are applied (8%)
- • Diarrhea
- • Fever
- • Upper respiratory infection
- • Urinary tract infection
- • Vomiting
- Eye feels irritated 7,786
- Fever 4,066
- Eye ache 3,808
- Feeling sick to your stomach 3,623
- Loose stools 3,562
- CMV infection 1,756
- Low white blood cell count 1,096
- Fever 940
- Diarrhea 916
- Low white blood cell count 914
To avoid eye injury or contamination, do not touch the bottle tip to your eye or any other surface. Do not use Vevye while wearing contact lenses. If you wear contacts, remove them before using the drops. You can put them back in 15 minutes after using Vevye.
Valganciclovir can cause serious side effects, including: - Lowered blood cell counts. This can lead to infections and bleeding. - Fertility problems in both men and women. - Birth defects if taken during pregnancy. - Cancer. Talk to your doctor about these risks.
It is not known if Vevye will harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Cyclosporine can pass into breast milk after being taken orally, but it is unknown if it passes into breast milk from eye drops. Talk to your doctor if you are breastfeeding.
This medicine can cause birth defects. Do not take it if you are pregnant or plan to become pregnant. Breastfeeding is not recommended while taking this medicine.
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How to Read This cyclosporine vs valganciclovir Comparison
cyclosporine is classified in the Calcineurin Inhibitor (Immunosuppressant) drug class, while valganciclovir sits within the Antiviral (Nucleoside Analog) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, cyclosporine has 22,845 submissions while valganciclovir has 5,622. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to taking these two medications together can increase the risk of damage to your kidneys.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between cyclosporine and valganciclovir - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.