clarithromycin vs lansoprazole
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Side-by-side comparison of clarithromycin and lansoprazole. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
Combination Therapy with Clarithromycin and Amoxicillin Clinical Impact: Concomitant administration of clarithromycin with other drugs can lead to serious adverse reactions, including potentially fatal arrhythmias, and are contraindicated. Intervention : See Contraindications and Warnings and Precautions in prescribing information for clarithromycin.
Biaxin
Prevacid
Clarithromycin is an antibiotic that fights bacterial infections. It belongs to a class of drugs called macrolides.
Lansoprazole is a medicine that reduces the amount of acid in your stomach. It belongs to a class of drugs called proton pump inhibitors (PPIs).
Clarithromycin treats mild to moderate infections caused by certain bacteria. It can treat bronchitis, sinus infections, pneumonia, and throat/tonsil infections. It also treats skin infections, ear infections in children, certain mycobacterial infections, and H. pylori infections that cause ulcers.
Lansoprazole can treat several conditions caused by too much stomach acid. It can heal duodenal and gastric ulcers. It also treats heartburn (GERD) and a damaged esophagus (erosive esophagitis).
Clarithromycin works by stopping the growth of bacteria. It prevents bacteria from making proteins they need to survive. This helps your body fight off the infection.
Lansoprazole works by blocking the enzyme in the stomach that produces acid. This helps to lower the amount of acid made. Lowering acid helps to heal damage and relieve symptoms.
- • Abdominal pain
- • Diarrhea
- • Nausea
- • Vomiting
- • Taste changes
- • Diarrhea
- • Abdominal pain
- • Nausea
- • Constipation
- Drug Interaction 2,906
- Nausea 2,214
- Dyspnoea 1,959
- Diarrhoea 1,937
- Malaise 1,650
- Chronic Kidney Disease 32,775
- Acute Kidney Injury 18,670
- Renal Failure 13,811
- End Stage Renal Disease 9,782
- Renal Injury 9,520
Clarithromycin can cause severe allergic reactions. Stop taking it and get medical help right away if you have signs of a reaction. This medicine can also cause heart rhythm problems (QT prolongation) and liver problems. Tell your doctor if you have heart or liver issues. Clarithromycin may increase the risk of death in patients with coronary artery disease.
Lansoprazole may hide the symptoms of stomach cancer. If you have a poor response or early return of symptoms, your doctor may do more tests. Long-term use of PPIs like lansoprazole may increase your risk of bone fractures. It may also cause low magnesium levels or Vitamin B-12 deficiency.
Clarithromycin is not recommended during pregnancy unless there are no other options. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if clarithromycin passes into breast milk, so talk to your doctor before breastfeeding.
Talk to your doctor if you are pregnant or plan to become pregnant. Lansoprazole may affect bone development in the fetus. If you take lansoprazole with clarithromycin, also consider clarithromycin's pregnancy risks.
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How to Read This clarithromycin vs lansoprazole Comparison
clarithromycin is classified in the Macrolide Antibiotic drug class, while lansoprazole sits within the Proton Pump Inhibitor (PPI) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are split between OTC and prescription status, which affects access and supervision.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, clarithromycin has 10,666 submissions while lansoprazole has 84,558. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to clarithromycin can cause serious and potentially fatal heart rhythm problems when combined with certain other drugs.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot represent individual circumstances. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This registry does not provide medical, treatment, substitution, or medication-change directions for clarithromycin or lansoprazole.
Registry boundary: This comparison displays source-record fields and does not provide individualized medical direction.