buprenorphine (pain) vs mirtazapine
Side-by-side comparison of buprenorphine (pain) and mirtazapine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Examples: Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue).
Recommendation: Watch for signs of a reaction like tremors or diarrhea and make sure your doctor knows you are taking both.
Belbuca, Butrans
Remeron
Belbuca is a medicine used to treat severe, long-lasting pain. It contains buprenorphine, a type of opioid pain reliever.
Mirtazapine is a medicine used to treat depression in adults. It can help improve your mood and energy levels.
Belbuca is used to manage severe, ongoing pain that needs an opioid medicine. It is for pain that cannot be well-treated with other options, like immediate-release opioids. Because of the risks of addiction, abuse, misuse, overdose, and death, Belbuca should only be used if other treatments don't work, aren't tolerated, or aren't enough to manage your pain.
Mirtazapine is used to treat major depressive disorder (MDD) in adults. This condition can cause you to feel sad, lose interest in activities, and have trouble with sleeping or eating. Mirtazapine can help improve these symptoms.
Belbuca contains buprenorphine, which is a partial opioid agonist. It works by attaching to certain receptors in the brain and body. This helps to decrease the feeling of pain.
Mirtazapine works by affecting certain chemicals in the brain called neurotransmitters. It helps to increase the levels of norepinephrine and serotonin. These chemicals can help improve mood and reduce symptoms of depression.
- • Nausea
- • Constipation
- • Headache
- • Vomiting
- • Dizziness
- • Feeling sleepy
- • Increased appetite
- • Weight gain
- • Dizziness
No adverse event reports.
- Feeling sick to your stomach 4,838
- Feeling tired 4,714
- Accidentally falling down 4,026
- Loose or watery stools 3,961
- Harm from different substances 3,705
Belbuca can lead to addiction, abuse, and misuse, which can result in overdose and death. It can also cause serious, life-threatening breathing problems, especially when you first start taking it or after a dose increase. Accidental exposure, especially in children, can be fatal. Taking Belbuca with benzodiazepines (like Xanax or Valium) or other depressants (including alcohol) can cause severe sleepiness, breathing problems, coma, and death. If you are pregnant and use Belbuca for a long time, your baby could have withdrawal symptoms after birth.
Antidepressants may increase the risk of suicidal thoughts and behaviors in young adults. Your doctor should closely watch you for worsening depression or suicidal thoughts. Mirtazapine is not approved for use in children.
Using Belbuca for a long time during pregnancy can cause withdrawal symptoms in the newborn. Talk to your doctor if you are pregnant or plan to become pregnant. Breastfeeding is not recommended while using Belbuca.
Tell your doctor if you are pregnant or plan to become pregnant. Mirtazapine should be used during pregnancy only if clearly needed. Talk to your doctor if you are breastfeeding.
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How to Read This buprenorphine (pain) vs mirtazapine Comparison
buprenorphine (pain) is classified in the Partial Opioid Agonist drug class, while mirtazapine sits within the Noradrenergic and Specific Serotonergic Antidepressant (NaSSA) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, buprenorphine (pain) has 0 submissions while mirtazapine has 21,244. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these drugs both change how your brain uses serotonin. when used together, they can cause serotonin levels to become dangerously high.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between buprenorphine (pain) and mirtazapine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.