buprenorphine/naloxone vs mirtazapine
Side-by-side comparison of buprenorphine/naloxone and mirtazapine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Examples: Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue).
Recommendation: Monitor for symptoms like fever, sweating, or muscle twitching and contact your healthcare provider if they occur.
Suboxone
Remeron
Suboxone film contains buprenorphine and naloxone. It is used to treat opioid dependence as part of a complete treatment plan.
Mirtazapine is a medicine used to treat depression in adults. It can help improve your mood and energy levels.
Suboxone film is used to treat opioid dependence. Opioid dependence means you are addicted to opioid drugs. This medicine should be used with counseling and support.
Mirtazapine is used to treat major depressive disorder (MDD) in adults. This condition can cause you to feel sad, lose interest in activities, and have trouble with sleeping or eating. Mirtazapine can help improve these symptoms.
Buprenorphine is a partial opioid agonist, meaning it has some opioid effects. Naloxone is an opioid antagonist, which blocks the effects of opioids. Together, they help reduce cravings and withdrawal symptoms without causing a strong "high."
Mirtazapine works by affecting certain chemicals in the brain called neurotransmitters. It helps to increase the levels of norepinephrine and serotonin. These chemicals can help improve mood and reduce symptoms of depression.
- • Mouth numbness
- • Tongue pain
- • Mouth redness
- • Headache
- • Feeling sick to your stomach
- • Feeling sleepy
- • Increased appetite
- • Weight gain
- • Dizziness
- Feeling sick to your stomach 138
- Throwing up 92
- Reaction at the injection site 90
- Headache 79
- Problem with the medicine being substituted 73
- Feeling sick to your stomach 4,838
- Feeling tired 4,714
- Accidentally falling down 4,026
- Loose or watery stools 3,961
- Harm from different substances 3,705
Buprenorphine can be abused, like other opioids. Taking Suboxone with other depressants like alcohol or benzodiazepines can cause serious breathing problems, coma, or death. Keep Suboxone out of the reach of children, as it can cause severe breathing problems and death if they take it. Using opioids for a long time during pregnancy can cause withdrawal symptoms in the newborn.
Antidepressants may increase the risk of suicidal thoughts and behaviors in young adults. Your doctor should closely watch you for worsening depression or suicidal thoughts. Mirtazapine is not approved for use in children.
If you are pregnant or plan to become pregnant, talk to your doctor. Using Suboxone during pregnancy can cause withdrawal symptoms in the baby after birth. Buprenorphine passes into breast milk, so talk to your doctor before breastfeeding.
Tell your doctor if you are pregnant or plan to become pregnant. Mirtazapine should be used during pregnancy only if clearly needed. Talk to your doctor if you are breastfeeding.
How to Read This buprenorphine/naloxone vs mirtazapine Comparison
buprenorphine/naloxone is classified in the Partial Opioid Agonist / Antagonist drug class, while mirtazapine sits within the Noradrenergic and Specific Serotonergic Antidepressant (NaSSA) class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, buprenorphine/naloxone has 472 submissions while mirtazapine has 21,244. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to these medications both affect a brain chemical called serotonin, which can lead to a dangerous buildup if taken together.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between buprenorphine/naloxone and mirtazapine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.