buprenorphine/naloxone vs cyclobenzaprine
Side-by-side comparison of buprenorphine/naloxone and cyclobenzaprine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
Examples: Selective serotonin reuptake inhibitors (SSRIs), serotonin and norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants (TCAs), triptans, 5-HT3 receptor antagonists, drugs that affect the serotonin neurotransmitter system (e.g., mirtazapine, trazodone, tramadol), certain muscle relaxants (i.e., cyclobenzaprine, metaxalone), monoamine oxidase (MAO) inhibitors (those intended to treat psychiatric disorders and also others, such as linezolid and intravenous methylene blue). Examples: cyclobenzaprine, metaxalone Diuretics Clinical Impact: Opioids can reduce the efficacy...
Recommendation: Tell your doctor if you feel very agitated, have a fast heartbeat, or lose coordination while taking these together.
Suboxone
Flexeril, Amrix
Suboxone film contains buprenorphine and naloxone. It is used to treat opioid dependence as part of a complete treatment plan.
Cyclobenzaprine is a muscle relaxant. It helps relieve muscle spasms and pain.
Suboxone film is used to treat opioid dependence. Opioid dependence means you are addicted to opioid drugs. This medicine should be used with counseling and support.
This medicine treats muscle spasms caused by painful conditions. It is meant to be used with rest and physical therapy. It should only be used for a short time, usually 2 to 3 weeks.
Buprenorphine is a partial opioid agonist, meaning it has some opioid effects. Naloxone is an opioid antagonist, which blocks the effects of opioids. Together, they help reduce cravings and withdrawal symptoms without causing a strong "high."
Cyclobenzaprine works in the brain and spinal cord to relax your muscles. It reduces muscle spasms, which helps to relieve pain and improve movement. It does not directly work on the muscles themselves.
- • Mouth numbness
- • Tongue pain
- • Mouth redness
- • Headache
- • Feeling sick to your stomach
- • Drowsiness
- • Dry mouth
- • Fatigue
- • Headache
- Feeling sick to your stomach 138
- Throwing up 92
- Reaction at the injection site 90
- Headache 79
- Problem with the medicine being substituted 73
- Pain 4,873
- Tiredness 3,808
- Feeling sick to your stomach 3,304
- Headache 3,292
- Long-term kidney problems 2,749
Buprenorphine can be abused, like other opioids. Taking Suboxone with other depressants like alcohol or benzodiazepines can cause serious breathing problems, coma, or death. Keep Suboxone out of the reach of children, as it can cause severe breathing problems and death if they take it. Using opioids for a long time during pregnancy can cause withdrawal symptoms in the newborn.
You should not take this medicine if you are allergic to any of its ingredients. You should not take this medicine if you are taking a monoamine oxidase (MAO) inhibitor or have taken one in the past 14 days. Taking cyclobenzaprine with an MAO inhibitor can cause serious problems, including seizures and death. Also, do not take it if you have heart problems or an overactive thyroid.
If you are pregnant or plan to become pregnant, talk to your doctor. Using Suboxone during pregnancy can cause withdrawal symptoms in the baby after birth. Buprenorphine passes into breast milk, so talk to your doctor before breastfeeding.
It is not known if cyclobenzaprine can harm an unborn baby. Talk to your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
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How to Read This buprenorphine/naloxone vs cyclobenzaprine Comparison
buprenorphine/naloxone is classified in the Partial Opioid Agonist / Antagonist drug class, while cyclobenzaprine sits within the Muscle Relaxant class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, buprenorphine/naloxone has 472 submissions while cyclobenzaprine has 18,026. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to both drugs can increase serotonin levels in your brain, which may cause a rare but serious reaction called serotonin syndrome.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between buprenorphine/naloxone and cyclobenzaprine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.