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betamethasone vs fluocinonide

Side-by-side comparison of betamethasone and fluocinonide Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.

Drug Class
betamethasone Topical Corticosteroid
fluocinonide Topical Corticosteroid
Type
betamethasone Prescription
fluocinonide Prescription
Summary
betamethasone

Betamethasone dipropionate cream is a strong steroid medicine used on the skin. It helps reduce swelling, itching, and redness.

fluocinonide

Fluocinonide is a strong topical steroid medicine. It helps reduce swelling, itching, and redness of the skin.

What It Treats
betamethasone

This cream treats skin problems that cause swelling, itching, and redness. These problems are called corticosteroid-responsive dermatoses. It is for use in people ages 13 and older.

fluocinonide

This medicine treats skin problems like eczema, psoriasis, and allergies. It reduces swelling, itching, and redness caused by these conditions. It should only be used on the skin.

How It Works
betamethasone

Betamethasone is a type of steroid. It works by reducing inflammation in the skin. This helps to relieve itching and other symptoms.

fluocinonide

Fluocinonide is a corticosteroid. It works by reducing inflammation in the skin. This helps to relieve itching and other symptoms.

Common Side Effects
betamethasone
  • Stinging (in adults)
  • Skin getting thinner (in children)
  • Spider veins (in children)
  • Bruising (in children)
  • Shiny skin (in children)
fluocinonide
  • Burning
  • Itching
  • Irritation
  • Dryness
  • Skin thinning
FAERS Reports
betamethasone

No adverse event reports.

fluocinonide
  • Medicine not working 746
  • Psoriasis 544
  • Rash 441
  • Itching 406
  • Tiredness 281
Serious Warnings
betamethasone

This medicine can affect your hormone system. It may cause your body to make less of its own natural steroids. Using too much, using it for too long, or covering large areas of skin can increase this risk. This medicine may also increase your risk of cataracts and glaucoma. Tell your doctor if you have blurred vision or other vision problems.

fluocinonide

Do not use fluocinonide if you are allergic to it. Tell your doctor if you have any skin infections before using this medicine. Using too much, for too long, can increase your risk for side effects.

Pregnancy
betamethasone

Tell your doctor if you are pregnant or plan to become pregnant. Using large amounts of this medicine during pregnancy may increase the risk of having a low birth weight baby. Talk to your doctor if you are breastfeeding. Use on the smallest area of skin and for the shortest time needed.

fluocinonide

Tell your doctor if you are pregnant or breastfeeding. It is not known if fluocinonide can harm an unborn baby. Talk to your doctor about the risks and benefits.

Also Compare — Nearby Drugs

How to Read This betamethasone vs fluocinonide Comparison

betamethasone is classified in the Topical Corticosteroid drug class, while fluocinonide sits within the Topical Corticosteroid class. Because both drugs share the same classification, they are often considered interchangeable in theory — but clinical outcomes rarely track that cleanly. Both drugs are prescription-only, so a licensed provider must authorize use.

Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, betamethasone has 0 submissions while fluocinonide has 2,418. Those figures reflect cumulative reporting volume — not per-patient risk — so older, widely dispensed drugs typically look worse on count alone. No direct interaction between these two drugs is listed in our FDA-derived dataset, though co-prescription still warrants pharmacist review. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.

A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between betamethasone and fluocinonide — always consult your physician or pharmacist first.

Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.