allopurinol vs pegloticase
Side-by-side comparison of allopurinol and pegloticase. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
( 7.2 ) Pegloticase: Discontinue and refrain from initiating treatment with allopurinol tablets. Pegloticase Clinical Impact Concomitant use of allopurinol tablets and pegloticase may potentially blunt the rise of serum uric acid levels and increase the risk of pegloticase related anaphylaxis in patients whose uric acid level increase to above 6 mg/dL. Intervention Discontinue and do not institute allopurinol tablets therapy during treatment with pegloticase.
Recommendation: Stop taking allopurinol before starting pegloticase and do not take it again while you are on treatment.
Zyloprim
Krystexxa
Allopurinol is a medicine that lowers uric acid levels in your body. It helps prevent gout attacks and other problems caused by high uric acid.
Krystexxa is a medicine used to treat chronic gout in adults when other treatments don't work well enough. It helps lower uric acid levels in your blood.
This medicine is used to manage gout in adults. Gout causes painful attacks, joint damage, and kidney problems. Allopurinol is also used in adults and children with leukemia, lymphoma, and solid tumors who are getting cancer treatment. It helps manage high uric acid caused by the cancer treatment. It can also help adults who get calcium oxalate kidney stones often.
Krystexxa is used to treat chronic gout in adults. This is for people whose gout is not well controlled with other medicines. It helps lower uric acid levels in your blood to reduce gout symptoms.
Allopurinol works by blocking an enzyme called xanthine oxidase. This enzyme helps your body make uric acid. By blocking it, allopurinol reduces the amount of uric acid in your blood and urine.
Krystexxa contains an enzyme that breaks down uric acid in your body. This helps to lower the amount of uric acid in your blood. Lowering uric acid can reduce gout symptoms.
- • Diarrhea
- • Nausea
- • Increased liver enzyme levels
- • Gout attacks
- • Skin rash
- • Gout flares
- • Nausea
- • Infusion reactions
- • Joint pain
- • COVID-19
- Diarrhea 8,423
- Tiredness 7,965
- Difficulty breathing 7,659
- Feeling sick to your stomach 7,061
- Death 6,664
- Gout flare 539
- Increased uric acid in blood 378
- Reaction to the infusion 358
- Treatment not working as well 240
- Difficulty breathing 166
Allopurinol can cause serious skin reactions that can be deadly. Stop taking this medicine and get medical help right away if you get a skin rash or any other signs of an allergic reaction.
Krystexxa can cause serious allergic reactions, including anaphylaxis, during or after the infusion. You should receive Krystexxa in a healthcare setting where anaphylaxis can be treated. If you have G6PD deficiency, you should not take Krystexxa, as it can cause red blood cell problems.
Allopurinol may harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is not recommended to breastfeed while taking this medicine because it can pass into breast milk.
It is not known if Krystexxa can harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if Krystexxa passes into breast milk, so it should not be used when breastfeeding unless the benefit outweighs the risk.
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How to Read This allopurinol vs pegloticase Comparison
allopurinol is classified in the Xanthine Oxidase Inhibitor drug class, while pegloticase sits within the Recombinant Uricase class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, allopurinol has 37,772 submissions while pegloticase has 1,681. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to allopurinol can hide changes in your blood levels that warn doctors of a possible severe allergic reaction to pegloticase.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between allopurinol and pegloticase - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.