aliskiren vs sacubitril/valsartan
Side-by-side comparison of aliskiren and sacubitril/valsartan. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
major Known Drug Interaction
7 DRUG INTERACTIONS Avoid concomitant use with aliskiren in patients with estimated glomerular filtration rate (eGFR) less than 60. The concomitant use of ENTRESTO with aliskiren is contraindicated in patients with diabetes [see Contraindications (4)] . Avoid use with aliskiren in patients with renal impairment (eGFR less than 60 mL/min/1.73 m 2 ).
Recommendation: Avoid taking these medications together if you have diabetes or kidney problems. Your healthcare provider will need to monitor your kidney function closely or change your prescription.
Tekturna
Entresto
Tekturna is a medicine used to treat high blood pressure. It helps lower blood pressure, which can reduce the risk of strokes and heart attacks.
Entresto is a medicine that combines two drugs to help adults and children with heart failure. It helps to lower the risk of heart problems and hospital visits.
Tekturna is used to treat high blood pressure in adults and children who weigh at least 110 pounds and are 6 years or older. Lowering your blood pressure helps prevent strokes and heart attacks. It is important to manage high blood pressure with a healthy lifestyle too.
Entresto is used to treat heart failure in adults and children aged one year and older. It is for people whose heart does not pump blood well enough. Entresto can help reduce hospital visits and the risk of death from heart problems.
Tekturna works by blocking a substance in your body called renin. Renin helps to control your blood pressure. By blocking renin, Tekturna helps to lower your blood pressure.
Entresto works by blocking a substance in your body that can worsen heart failure. It also relaxes your blood vessels, which helps your heart pump blood more easily. This combination helps to improve how well your heart works.
- • Diarrhea
- • Low blood pressure
- • High potassium levels in the blood
- • Cough
- • Dizziness
- • Kidney problems
- Weakness 367
- Fall 356
- Feeling sick to your stomach 336
- Shortness of breath 314
- Headache 301
- Low blood pressure 11,457
- Death 9,093
- Shortness of breath 8,895
- Feeling dizzy 8,621
- Feeling tired 8,606
Tekturna can harm your unborn baby, even causing death. If you become pregnant, stop taking Tekturna right away and tell your doctor.
Entresto can harm an unborn baby, even causing death. If you are pregnant or become pregnant, stop taking Entresto right away and tell your doctor.
Tekturna can cause serious harm or death to an unborn baby. If you are pregnant or plan to become pregnant, talk to your doctor about other blood pressure medicines. Breastfeeding is not recommended while taking Tekturna.
Entresto can cause serious harm or death to an unborn baby. Do not take this medicine if you are pregnant. Breastfeeding is not recommended while taking Entresto.
How to Read This aliskiren vs sacubitril/valsartan Comparison
aliskiren is classified in the Direct Renin Inhibitor drug class, while sacubitril/valsartan sits within the Neprilysin Inhibitor / ARB Combination class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, aliskiren has 1,674 submissions while sacubitril/valsartan has 46,672. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known major interaction flagged in FDA labeling, attributed to both drugs target the same blood pressure system, which can cause the kidneys to stop working correctly or lead to high potassium levels. this risk is much higher for people with diabetes or existing kidney disease.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between aliskiren and sacubitril/valsartan - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.